HealingWell
Search Close Search
☰

Antidepressants don't work

Support Forums
>
Depression
✚ New Topic ✚ Reply
❬ ❬ Previous Thread |Next Thread ❭ ❭
Posted 4/25/2013 4:59 PM (GMT 0)
I've been suffering from depression for over a year now. I have tried every type of antidepressants except for the class that Cymbalta is in. None of them worked on me. My doctor says that Cymbalta is pretty much my last choice since she's running out of options.

I am also taking Methadone and Soma for chronic pain. Something is telling me that one or both of those drugs are negating the effect of the antidepressants. I tried to do some research on that, but couldn't really find an answer.

Has anyone here had similar problems with antidepressants and if so, what to do about it. I really don't want to take Cymbalta for any length of time since it's so horribly expensive. On the other hand, if it works, I guess it will be worth the expense since I really don't have a life these days with my depression making a recluse out of me.
Posted 4/25/2013 6:42 PM (GMT 0)
I take narcotic pain relievers too and they don't effect or mitigate my antidepressants. Cymbalta is an ssni I believe, and if you haven't tried them, I think you should give them a chance. I do much better with the ssni's than the ssri's. I take pristiq. I have taken Effexor for many years and it worked well. It is an ssni also.

I agree talking with your pharmacist could help. They know a lot about interactions with medications. I do know narcotics will make your depression worse, so I think you should give it a chance to make you feel better if it can. Cymbalta also helps with the pain from what I have heard.

I wish you the best.

Hugs, Karen
Posted 4/26/2013 12:35 PM (GMT 0)
If you have only been treated for one year it is unlikely that you have tried everything. It can take 2-3 months per drug for an adequate trial with titration up to the maximum dosage. In addition, sometimes combinations of medications work better than a single drug.
Posted 4/26/2013 1:32 PM (GMT 0)
I have had depression for over 10 years, i mean the one, where most of the days you wake up and think **** i'm still alive.

I have gone through most of the remedies available: SSRI's, SNRI's, Tricyclics, MAOi's, Herbal stuff, Meditation, Positive thinking, Socializing, Sport, Goal pursuing and the list goes on.

Only thing that ever made worth mentioning and lasting difference in how i feel was the MAOi - Nardil (Phenelzine).
If you haven't tried it, it's definitely worth a shot.

At my standpoint i wouldn't use the word antidepressants for other group depression medication, they are more like coffee or ibumetin for depression. Nardil really diminished my depression. It's a very powerful drug and it works for majority of people, like 90% or more, it just the side-effects that make people quit.

Good luck!
Posted 4/26/2013 2:56 PM (GMT 0)
I had to take a little ablifiy in order for my anti-depressants to work.
✚ New Topic ✚ Reply