Has This Happened To Anyone?

Very weird. I also have liver problems, with high numbers. I've never had a problem with things leaving my body though. Most problem I have is with what I can absorb.
I know my Psychiatrist has to be very careful with what she prescribes me, and I'm sure liver is one of the things she's careful about. Although that might just be my tablets for my liver, I'm not too sure.
With the 2 different antidpressants I've tried, I've not noticed any problems to the extent that your having.
When starting my mirtazapine though, I have had similar problems to what you describing. I also start to feel the effects of them almost immediately. Like within 2 days. It's supposed to take a couple of weeks for them to really get into your system. Within a week of feeling down though, I suddenly felt extremely perky, then I started to level out. And after a couple of weeks, I had no problems.

To be honest I've not really just stopped them coz I feel bad. The only time I've stopped them is about a year of taking mirtazapine/Zispin, they found I had a dangerous reaction to them, and had to stop them suddenly. I put feeling so low down to a mixture of home and health problems, and stopping so suddenly. Soon after that I started Sertraline. I didn't notice any problems really starting them, but she started me on the lowest dose, then slowely got me up to the 100mg a day I take now.

It may make them slower to take effect, but perhaps working up from a small dose is the way to go?

Everyone has a right to complain no matter what there situation. Even people who have everything they could ever wish for, will still be unhappy inside, and can even get lower than my level of happiness. Living with what I have has made me so much stronger, and I'm dealing with things a lot better than I used to. You sound you've had a lot of problems yourself, and have every right to be feeling as down as you do.

Once they can start treating my health issues I'll probably be fine and dandy, and once I get a grip on things i'll be all happy, and my old self, just with a few problems in the way. Things are sent to try us I guess, and depression is one of the biggest tests I've ever had to face.

It doesn't help when your having such bad experiances with your medication, and I'm really struggling for things to suggest for you. Even with my huge education on medications, I'm not up on anti-depressants. Perhaps I should research, now I have all this spare time.

If you need someone to talk to, you can always chat to me. My Msn should be hiding somewhere on my profile.

Try not to cut any medications that maybe helping you health wise. Even if it's just vitamins. From experiance I've found, the better your feeling in yourself, the better your mind will feel, and it will be less stressed out.

Take care, and hope things work themselves out
XxXxX

Even with liver problems, you should be able to take antidepressants safely with a lower dose. Work closely with your doctor to see if that works.

Lexapro and Zoloft both have minimal inhibitory effects on the liver enzymes, as does Wellbutrin. Remeron should be used very cautiously, if at all, because it sometimes has the rare side effect of increasing your numbers.

What kind enzymes?

Thanks.