I tried to go the "natural" herbal route. It did not work well for me. I never tried sam-e but I did try St. Johns Wort, 5-htp, nerve herbal blend formulas, many variations. I finally gave in and went to my physician and got started on a low dosage of Celexa. It takes a while to work but I am feeling better everyday. I had a very severe reaction to a medication in January and was very leary of going the pharmacuetical route, but I guess at this point I do not have a choice if I want to feel good. Be careful with herbal formulas, they are not always what they claim to be and how do you determine the dosage properly? I think they may work for some people, but not on major depression or bipolar.
Hope things get better for you soon.
Gem