Good Morning and Welcome to HealingWell,
When taking Pristiq, it’s important to give it time to work. Everybody responds differently to treatment. In general, it can take several weeks to feel the full benefit of a prescription antidepressant, although some people will start to feel better sooner. Remember, it's important to take Pristiq as prescribed by your health care professional. Don't stop taking Pristiq without first talking to your health care professional, even if you don't feel results right away.
Good luck on this med and may it be the one that works for you. :)
Kitt