I posted about 4 weeks ago about my doc taking me off effexor and putting me on Wellbutrin overnight. I seen him yesterday, and he told me just to hang in there a few more weeks.----My depression seems endless, two weeks ago my husband had to shut down his building supply manufacturing company due to the poor economy. Not only is my husband out of work, and facing all the problems that will follow, my son, daughter, and son-in-law all worked for him. I cannot get this out of my mind, but thought that maybe the new medication would help me more than it has. I have lost weight, I cannot sleep, no energy,etc. Has anyone made this med switched and have taken this long to feel better ? I appreciate anyone's input and support. I have had depression on and off for over 25 years. Thank you so much.