I was diagnosed with severe ulcerative colitis in 2008, and in order to control the anxiety that came with the disease my doctors placed me on Zoloft. The highest milligram I'd been on was 100 mg. I can't say that it had much effect, but maybe at the time helped with anxiety. In other words, I hadn't really had problems with anxiety/depression before my diagnosis. I had a few ups and downs in college & highschool but I wouldn't have labeled myself as depressed, as I never had the symptoms. In the past couple of years I've achieved remission with my ulcerative colitis and therefore was able to taper off most of the medications that were treating it. My colon is doing fine - great, in fact, as I just had a colonoscopy in November which showed no signs of active disease. Coupled with tapering off of my UC medications, I decided I wanted to get off of the Zoloft too. I started a very, very slow taper in September of this year, cutting down from 30 mg. to zero by Christmas. The holidays went fine - they were actually great. But in the past couple of weeks I seemed to have plummeted. I am extremely irritable and sensitive. I have horrible crying fits, and last night I even found myself moaning and screaming. My boyfriend is wonderful and patient but I just don't know how to describe that I'm just in pain somehow. I hate everything. I am not looking forward to anything. I'm negative, jealous, and unhappy, and my self-esteem is in the dumps. I feel like I want to bust out of my own skin. I want to be happy again, but I don't want to go back on medication. I don't know if this is symptoms of the withdrawal - this mania, really. And if it is withdrawals I'm so angry that I took the Zoloft in the first place - because it has changed me. Has this happened to anyone else? How long does this last? I read some places that it can take several months for it to completely leave your system. Other people complained of muscle soreness, dizziness, etc. after tapering off, but I'm just feeling like Jekkyl & Hyde. I need someone to tell me there's a light at the end of this tunnel and that I can find my old self without going back on medication.