Taking codeine with anti-depressants

Hi everyone,

Okay this may just be me but I have also found other people online which also verify that taking codeine can actually cancel out the effects of an anti-depressant and I am sure this is the case for me as I was taking roughly around 6 x 30/500 co-codamol per day for back pain and I am on day 15 of taking 150 mg of Sertraline but I noticed if I went a day or two without taking codeine then I would feel a lot more with it and stable so please be careful with what you are taking.

I think that it is okay to take it everynow and again and I am sure a lot of people out there don't have a problem with it at all but I know I definitely did and now I am giving it a few days without the codeine and I already feel more stable.

I think it is because codeine is pretty much seen as a depressant and any drug that can alter brain chemicals can interact with your anti-depressants but just be careful as it has really opened my eyes.

Yeah I cannot believe it now as it does make so much sense but there is so little awareness about it.

I used to take them with Paxil and I didnt feel any adverse effects but that was perhaps because I had already been taken Paxil for a long time and the tablets were in my system and working by then but because this time I have noticed when the anti-depressants are working or not because I have been feeling so bad.

I cant assume that it will have the same affect on everyone who takes the two but I seriously think more research needs to be done into the interactions as lets face it, how can they be sure what is going to interact with anti-depressants when they dont even know for sure what anti-depressants actually do to the chemicals of the brain.

Be careful peeps

Yeah I know and I think I only took a couple but now I have not had any for like 48 hours and I do notice a difference in the clarity of my mind.

I still think the Setraline are still yet to kick in but it has only been 15 days so that is pretty early really isnt it?

I haven't noticed any issues. I have been taking the codeine-based meds for many years now, in small doses at night. I started anti-depressants 2 plus years ago. During the day, I use tramadol for pain killers.