Long term med (Welbutrin) that stopped working

I took it for awhile. I didn't like the way it made things taste. I was taking Effexor at the time also so I didn't have any trouble with weaning off. I just stopped taking it.

Do you take a high dose? Could an increase possibly help?

Is there any situation going on that could be adding to your depression?

Are you saying the doc wont let you try something else?

I hope you find what works for you. Maybe the Wellbutrin will start working again...

Hugs, Karen...

Thank you for the replies. I take 300mg. XL. I think it goes up to 450mg. I'll ask my P-doc about it next appointment. I don't understand why / how I'm taking 60mg Prozac, 300mg Bupropion Xl, and 20mg Latuda and am still depressed. I get worried that something is seriously wrong with me. Is depression supposed to last this long? I feel scared sometimes.

Karen - the Latuda is an Second Generation AP approved by the FDA for the treatment of bipolar depression. You know what? I'm really really scared, crying and thinking of "S." I'm very scared that I have treatment resistant depression. I pray, I try to think positive, I force myself to get out, I try to find pleasure in being with my fur-babies. I can't shake this depression. I am 53. I do not have children or Grand children. I live alone. I've never been so lonely and so seemingly out of place before. I've had depression since I was in high school. For some reason, I can't get a reprieve. Even a short period without this deep sadness would be helpful. I can't tolerate the feeling that I might not get better, that I will face old age like this. I want to believe that all depression can be treated with the right meds but there are many people out there who live their whole lives like this. I don't want to be one of them. It seem inhumane to expect us to live like this.

Thank you for your support.

Karen, thank you for your support. I have taken Cymbalta (SSNR) and it shredded my stomach. When I stopped taking it, my stomach issue got better. I have no idea why but our bodies are all so different. Unfortunately, last night I stumbled upon a blog with comments from many people with treatment resistant depression. I don't even like to think of depression like that but many do suffer for years without help from meds and therapy. I am not ready to label my depression like that quite yet but it seems to be headed in that direction and that frightens me.

Thanks, Karen. Yeah, I am either Bipolar II or I have atypical Depression. I am able to experience good feelings. I just get very depressed every day and I cry wondering when will I feel better.

On a side note, my PCP ordered an ultrasound of my Thyroid. My TSH always comes up in the "normal" range but in July my T4 tested LOW and in September, my T3 uptake tested LOW. I tested negative for Hashimoto's disease but I've read a lot about "Low T3 syndrome" and "Under conversion" of T4 to T3. I will see my P-doc on Monday and tell him about the new development. He cares about me and has even prescribed 5mg Ritalin (I can sleep through it...lol) to help me "function" during this time of either bipolar depression hypersomnia or SE of Latuda 20mg (lowest dosage). From what I understand, some people have a thyroid that cannot convert the T4 to T3. T3 is important and this could explain why I am so lethargic and fatigued. I'm wondering, which came first...the chicken or the egg, so to speak? I bet my P-doc will prescribe a synthetic T3 just to see how it makes me feel. He is the one who ordered the T4 back in July. I took synthetic Thyroxine (T4) but I got VERTIGO. I recently got my labs back from September testing which included a little more about my thyroid but she still didn't order a full panel.

Anyway, thanks for listening and caring.

Thanks, Karen. Are you in the U.S. and on an HMO? After researching thyroid (stop the madness!), I am pretty sure doctors do NOT want to refer someone to an Endo. Basically, patients with thyroid issues are monitored several times per year and that costs money. I suppose it's my "depression" filter, but I don't expect my doctors to really *want* to help me feel better. isn't that sad? I used to be an Optimist.

I like reading your posts too and the Healing Well community.