Posted 9/27/2010 8:48 PM (GMT 0)
I have ulcerative colitis, for which one of the standard treatments is medium to high dose of prednisone for weeks to months (some are on permanent low prednisone therapy). During my last UC flare-up, I was taking 60 mg/day of prednisone for months. I have been pre-diabetic (fasting BGL 100-120) for years, but the prednisone raised my blood sugar to the 300-400 range. I couldn’t figure out why I was feeling so bad, so I went to my PCP, and she had me do a fasting BGL and A1C, they were 332 and over 12%. She immediately put me on MetFormin and ordered a meter for me. When the nurse was teaching me to use the meter my BGL was over 400.
I took my first MetFormin later that day and was beginning to feel better within an hour, and steadily improved throughout the next week or so. While discussing it with my PCP, she told me that prednisone can raise BGL as well as WBC, and that the prednisone tipped me over from pre-diabetic to type two. The good news was that it usually (but not always) resolves in a few months. After a few months, my diabetes had not resolved and I began to resolve myself to the not always category. But happily, after 10 months of being steroid free, it seems to have finally resolved and I haven’t taken any MetFormin for several weeks now with twice/day meter readings of between the high eighties and 120.
I also had a urinary tract infection during that time, and the prednisone induced high WBC was masking the diagnosis for that, but when a urine test finally showed that, and was treated with Cipro, I got rid of that too.
The bottom line is the answers to your questions are YES and YES, and both can mask diagnoses for other issues. And when/if I have another UC flare, I don’t know what I’m going to do. Take the prednisone and go back on the MetFormin or try other treatments for the UC flare.