Topamax is one of the three seizure medications I take. I had a hard time for a week or two adjusting to it, by that I mean being sleepy or foggy. Other than that, I have had no problems with Topamax.
I used to have to take Imitrex for migraines and now I rarely do. Topamax has really helped a lot with the headaches.
Good luck to your wife!
Carla