I was diagnosed with fibro over 23 years ago and in that time have taken many, many prescript
ions, supplements, alternative treatments, psychotherapy, you name it, I tried it. My concern for you is your Crohn's and the side effect I had from Cymbalta and Pristiq. I began Cymbalta at the 30 mg dose and stayed at that dose for 30 days and then went to 60 mg. At 30 mg, I began to have diarrhea...not every day so at first I didn't associate it with the Cymbalta. I also have irritable bowel, affected by weather changes and anxiety and stress. When I went to 60 mg, and did this because the 30 mg did nothing for my depression and anxiety, the diarrhea became extremely bad. So bad that I didn't want to leave the house. I discussed this with my psychiatrist and she told me to split the dose, 30 in the am, 30 in the pm. Made no difference. I really thought I was ready for Depends. So, she took me off the Cymbalta after about
three months, and put me on Pristiq, telling me in no way would I have the same side effects. I started on 50 mg and was told the majority of people stay on 50, never needing to go to 100 mg. Guess what? After six weeks, I was at 100 mg because the 50 mg did nothing...depression and anxiety seemed even worse than before and with it came diarrhea, just as bad as when I was on Cymbalta. Psychiatrist said stay with it, the diarrhea will go away. After several weeks of not getting any relief of depression or anxiety, or diarrhea, I called her and said get me off this drug. I tapered off it and as of this past weekend, I'm off Pristiq.
For the past 23 years, I have been subscribing to a journal, FM News Network, which is written for physicians as well as patients. Some of the articles are difficult to understand, written for physicians, explaining studies that are being conducted, but I muddle through them and get the gist of what they are trying to tell me. This last issue has an article called " depression and anxiety, is your fibro to blame?" The article discusses several different studies being conducted; response to pain, FM versus depression, influence of sleep, etc. An article written by Robert Dantzer, Ph.D of the University of Illinois in Urbana states "Many serotonin boosting antidepressants can tone down inflammation, although each class differs in its cytokine reducing ability. on the other hand, cytokines that promote inflammation can lower the production of serotonin. This association may explain why LESS THAN 50% OF PATIENTS BENEFIT FROM ANTIDEPRESSANTS, BECAUSE IMMUNE ACTIVATION CONTINUES TO IMPAIR BRAIN FUNCTION AND TOY WITH EMOTIONS." This is only a portion of the article, but it was certainly enough for me to realize that SNRIs simply do not work for me. I have gone back into psychotherapy with a wonderful woman I worked with over two years ago who helped me taper off an antidepressant back then, along with an antianxiety, and a sleeping pill. She has now introduced meditation along with psychotherapy.