I also have elevated ANA. A certain percentage of people from the general population will have a positive ANA if tested. It took probably 20 years for my ANA to go up to the next higher titer, but that is not a prediction of what yours will or will not do.
When my ANA number went up my hashimotos numbers (autoimmune attack of the thyroid) were also rising, and the hashimoto's numbers were rising steeply. So if you are really concerned, I will tell you that getting off of wheat, soy, and dairy, on my doctor's instructions, seems to have a strong effect of bringing down my autoimmune numbers, as was her plan. It's a serious commitment to a change in eating, tho, and I wasn't initially able to stick to it. Since I know a member from another forum who says she has absolutely no trouble making various dietary changes, just in case you are like her, I thought I may as well mention it.
I visit a few different forums and have probably seen 6 to 8 people say that prednisone helped their fibromyalgia. My guess of the number.
Is there inflammation in fibro? I think so. I followed research into that topic fairly religiously for a few years and I posted about
those studies here at the next link. I think the 2015 study I discuss from Kosek et al., and the 2014 publication of Jerrod Younger and his partners' LDN study(study actually completed in 2012?) present interesting possibilities. They are near the very top of this group of summaries. Probably none of us here would have enough of a medical education to know if "neuroinflammation" would be helped by prednisone.
https://www.healingwell.com/community/default.aspx?f=24&m=2756942&g=2756942#m2756942
This may not be clear to you yet, but when you have read more it may become clear, so I will add this:
There are also other possible sources of inflammation. What if it is the fascia of the muscles that gets inflamed? But I haven't read anything new about
that theory in a long time (years). What if the Spanish team's findings which are suggestive of inflammation from mitochondrial damage are closer to the truth? Could different fibromyalgia patients have different sources of inflammation? What if fibro patients expeience different levels or extremes of inflammation? That seems likely, just looking at the genetic studies and different results in blood tests for both SED rates and "high sensitivity" CRP tests.
Post Edited (Rockon) : 10/20/2015 1:04:22 AM (GMT-6)