Kathy, I have recently increased my cymbalta to 90 mg a day. I take mine in the mornings; I was on 60 mg a day for a few years and felt that I needed a boost. It wasn't that I had built up a tolerance, it was that my life had radically changed [for the better, but positive stress is STILL stress :] I met with a new doc and we increased it. I don't buy the 90mg tabs, I buy both the 60 and the 30, then take them together. I hope you are able to find a dosage that works for you. If you have any questions, I am always happy to chat. Peace!