Hi, JoAnn. That can be frightening to mix up the pills. My dh and I do not have the daily pill box, but we have enough pills to take each day. My dm, on the other hand, needs the pill box. She has the 4 boxes per day variety. Breakfast-Lunch-Dinner-Bedtime. My sister or I have do refill it each wk, also. When she is w/ me I label the bottles, just like I do w/ my own and dh's. I make notation of '1 pill 2x a day', 'HBP' and if it goes in the B-L-D- or B box. If there are some that remind you of each other, mark the med name on one w/ yellow hi lighter.
I also do important things (where my brain HAS to be ON) early in the morning. As the day goes on, my brain fades away. lol. Find your best time of day to do important things. If you are still not sure, ask someone you trust to set your meds in place for you.
Good Luck!!
God bless. Alice.