Msbunky and MrsMike - Watch mixing tramadol and Cymbalta! They both increase serotonin. I wouldn't dare take them together after having serotonin syndrome from mixing Flexeril and tramadol and just taking one extra small tramadol.
I just started Cymbalta last night and I'm up with a headache and insomnia. So far I haven't had a positive effect, as I just had to take the Vicodin again. I'm supposed to take Cymbalta plus Robaxin, but I'm trying them out separately because I need to know what effects they will have. Flexeril was about as effective as Tylenol and gave me a headache.