crackling joints and drug effectiveness over time

Just wondering about this.. have had horrible cracking knees forever, but now wrists, ankles, neck, etc... the last time I squatted to reach something low, and both knees cracked, a guy next to me said it sounded like a drive by shooting!

Also wondering - does the effectiveness of these pain drugs wear off in time? I noticed when I started on amitriptyline, the first week the dose was great, then slowly it gave less pain relief, and as I increased the dose slowly from 20mg to 50mg, after each increase, there was great pain relief for a week and then it seemed to be less effective... Same with using tramadol. Great relief initially, now not so much....

I don't have the fibro pain everyday but thats what my doctor thinks it is. But after the flare I had my shoulders, neck, back, wrists and ankles were crackling and popping for about a month but now it's not so bad. Today I'm getting these weird random pains through out my body but it's not severe and they are only lasting for a minute or so. ?... My right foot is tight and hurts and my left wrist hurts, which is weird because I'm right handed.

I have tramadol but I haven't had to use it much so I don't know about the effectiveness over time. With the wellbutrin (generic) and xanax (generic,too) I've built up a tolerance or something and have had to raise my dose a little on the xanax but I haven't done that with the wellbutrin. When I was taking wellbutrin a couple years ago i was up to 400 mg a day, I don't think you can take much more than that but then I quit it for a year and unfortunately had to start taking it again in july. Now I'm taking 300 mg a day, I have to say though, this generic stuff they're giving me isn't very good. I wish I could afford the name brand.