I know there has been much discussion on Cymbalta. I just had my first apt. with my new doctor and he put me on cymbalta. Last weekend was pretty tough. I was totally out of it and had bad diareha. Even had to get some pedialyte to help me so I wouldn't get dehydrated. Late Sunday I started coming out of it and felt so much better. This week has been great. Overall I feel better but was sure to discuss all the side affects with my husband so he knows what to watch for. I'm getting up better in the morning and my entire day at work is better. I did have some increased achne and trouble sleeping a couple nights. I hope this too will pass. The one thing that I still have problems with each day and night is increased musle pain in my legs. I will talk with my doctor about it but overall feeling much better. Going to the pharmacy today to get my 30 day free sample. I know it is more expensive but he cut out some of my other meds and I finally have insurance so hopefully it will work out for me. Has anyone had additional problems after they got used to it or does it quit working for you after a period of time? Thanks for your feedback.