I took Prempro for about a year and then was taken off it for safety reasons. I haven't had any hormones since and it hasn't affected my pain any worse so I don't think that will really make a difference.
Have you googled the side effects of the supplement you added? If it doesn't show up, then google the ingredients, one by one, in it and you might be able to tell that way.
You also might have something else along with fibro going on, too. This happened to me this past winter. Once I got a good diagnosis and put on the right medication, my pain has lessened immensely. I only take over the counter pain relievers.
Let us know what you find out. I'm really curious now. I'm sorry you are going through this but you will figure it out.
Sherrine