I'm not sure if this has been shared here before, but I stumbled across this tonight:
"Using a special microscope, they studied skin biopsies from the palms of their fibromyalgia subjects. They noted a big jump in sensory nerve fibers at certain sites that are small muscular valves in the skin's blood vessels. The valves are called arteriole-venule (AV) shunts and occur only in the palms of the hands and the soles of the feet.
In the hand, they play a role in regulating body temperature, opening to permit blood to bypass capillaries and save heat and causing the hands to get cold. Under cold conditions, the shunts become especially active, perhaps a reason why the cold bothers fibromyalgia patients so much. The pathology the scientists discovered among the AV shunts and the resulting alteration of blood flow could also be the source of achiness, muscle pain, poor sleep, and cognitive issues linked to the disorder. "
http://news.yahoo.com/researchers-possible-biological-basis-fibromyalgia-204400241.html