IgE vs. IgG. MOVED. I encourage you to read the last post from me in the food thread

The mast cell and their IgG receptors and their roles in tissue inflammation,
"Mast cells are effector cells of the innate immune system, but because they express Fc receptors (FcRs), they can be engaged in adaptive immunity by antibodies. Mast cell FcRs include immunoglobulin E (IgE) and IgG receptors and, among these, activating and inhibitory receptors. The engagement of mast cell IgG receptors by immune complexes may or may not trigger cell activation, depending on the type of mast cell. The coengagement of IgG and IgE receptors results in inhibition of mast cell activation. The Src homology-2 domain-containing inositol 5-phosphatase-1 is a major effector of negative regulation. Biological responses of mast cells depend on the balance between positive and negative signals that are generated in FcR complexes. The contribution of human mast cell IgG receptors in allergies remains to be clarified. Increasing evidence indicates that mast cells play critical roles in IgG-dependent tissue-specific autoimmune diseases. Convincing evidence was obtained in murine models of multiple sclerosis, rheumatoid arthritis, bullous pemphigoid, and glomerulonephritis. In these models, the intensity of lesions depended on the relative engagement of activating and inhibitory IgG receptors. In vitro models of mature tissue-specific murine mast cells are needed to investigate the roles of mast cells in these diseases. One such model unraveled unique differentiation/maturation-dependent biological responses of serosal-type mast cells."


http://www.ncbi.nlm.nih.gov/pubmed/17498061

Post Edited (Rockon) : 4/13/2014 1:38:03 PM (GMT-6)

The post I moved was about food allergies and GMO foods. I copy and pasted the two posts that you wrote and made them one post...with a large space I between. Sorry you don't agree but these posts were about food.

Sherrine

I do read some of them but not all of them. They are extremely long and extremely technical and I don't have the time to go through them. It looks like you are copying and pasting things from articles which, by the way, is against forum rules, but I have left them up.

The fibro forum is very busy and I try to respond to most threads. I try to help members with the fibro issues they are dealing with at the moment. I did, though, do some research on the GMO foods.

Sherrine

Acheybody, I appreciate your effort to explain. For the record, here's how I feel about it.

It's frustrating because for at least three weeks I've talked over & over about mast cells. They are part of the immune system, as are IgE and IgG. The allergy article explains part of that activation of part of the immune system. That's why I posted just above about the relationship to IgG being in the Cort Johnson thread about fibromyalgia, and why I posted one of the original fibro study links showing IgG in the skin of fibro patients. And it's why I posted the one about the relationship of these things to at least some autoimmune diseases.

I've mentioned Dr. Theoharides video "Brain Allergy", several times, and lots of his other research relating to mast cells to fibro. Mast cells are the cells mediating allergies. Today it became a subject for the food thread.....but the Cort Johnson thread about mast cells doesn't belong in the food thread; and that shouldn't be in the food thread. It's an immune system topic. I'm not talking about diet or telling people what I think they ought to try eating or avoiding, or sharing what I eat.

I will drop the topic, but I hope mast cell discussions do not end up on a second class food thread again. And the food thread is second class in the minds of some members, which I say because clearly some people do not read things that are in the food thread, and thus could miss an important immune system topic.