New.
"Stanford University School of Medicine scientists have definitively linked mast cells, a class of cells belonging to the immune system, to the development of osteoarthritis, one of the world's most common causes of pain and immobility.
"...mast cells also produce a degradative protein, tryptase, that can rip up collagens and other molecules that form the cartilage in joints."
https://www.google.com/amp/s/medicalxpress.com/news/2019-05-mast-cells-crucial-osteoarthritis.ampA couple of years ago I had taken a cursory look around for studies of Rheumatoid arthritis which found mast cells participated in Rheumatoid arthritis. I knew from those that mast cells definitely participated in Rheumatoid Arthrits in synovial joints.
Titled:
Mast Cells are Important Modifiers of Autoimmune Disease: With so Much Evidence, Why is There Still Controversy?
Melissa A. Brown and Julianne K. Hatfield.
[Frontiers in Immunology is peer reviewed.]
"There is abundant evidence that mast cells are active participants in events that mediate tissue damage in autoimmune disease. Disease-associated increases in mast cell numbers accompanied by mast cell degranulation and elaboration of numerous mast cell mediators at sites of inflammation are commonly observed in many human autoimmune diseases including multiple sclerosis, rheumatoid arthritis, and bullous pemphigoid. In animal models, treatment with mast cell stabilizing drugs or mast cell ablation can result in diminished disease."
an example to verify the OA/mast cell connection.
Title: Mast cells are the main IL-17 producing cells in synovium of anti-citrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis patients. Suurmond et al. 2011
I also have this link in my
notes app.
2013 abstact (RA). Team with mast cell researcher Dr. Theoharides:
IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin.
http://www.ncbi.nlm.nih.gov/pubmed/2415283Post Edited (Rockon) : 6/25/2019 10:58:03 PM (GMT-6)