Prucalopride/resolor... side effects?

 Hi I just started these meds today. and within an hour of taking the tab i had the same symptoms my head is so light its unreal. But if it works it will be great, I guess we just have to give it time and allow our system to accept it.

please keep me updated on how u are doing

gino

tks Sarah.

I will do im a bit like ur self when it comes to it. its takes a bomb to move me. they have tried everything. but this is working for now but its only the first day.

take care

Hope it continues to work as well for you! Good luck. Can manage an occasional very small glass of wine but much more makes me feel terrible.. but then I've always been a lightweight ;-) so not sure if it's the drug or not. Presume you're in the UK?

Oh god really sorry to hear that :-( I had achey legs too but nothing like that bad.. Altho have to say nearly didn't take it on day 2 but wasn't as bad...Very bizzare. I have concerns over this drug and can't wait to get off it. Have a chat with your doc and you could perhaps go to 1mg per day and build up? Good luck... Keep in touch

how are you getting on with the pills? did you decide to keep trying them or ditch it altogether?

Hi Motoe.. welcome. I'm sorry to hear you're having such a hard time.

You'll find lots of others on the ostomies board too. Sounds like colonic inertia rather than IBS altho I'm no expert.. and there is a whole host of people who have had all sorts of tests, treatments and surgery for that who post on the ostomies forum. My situation is slightly different as I didn't have these problems BEFORE I had to have emergency surgery for peritonitis.. however an ileo isn't the only option surgically for CI. Most people seem to have a total colectomy to treat CI with possibly a temp ileo while things heal, then get reconnected. There is also the option of a J pouch (a sort of internal pouch instead of an ileo) - again you'll have to ask more experienced posters as I don't know a great deal about that. There's a woman on the ostomies forum ('tickledpink' I think) who is only 26 and having a total colectomy for colonic inertia. Just because of your age you shouldn't have to suffer... you need to make it very clear how this is affecting your quality of life and being unable to work is pretty extreme. I totally get the suffering though and know how miserable it is..

Anyway... Like you I'm about 6 weeks in now and the effects of resolor are definitely wearing off and I have to do a treatment of picolax once every 8-10 days. I've had the benefit of having an ileo and knowing how much better I felt with it than I do now. If it's any consolation, I'm most likely having mine put back and am actually thrilled about the prospect! I'm not keen on having a total colectomy as I've already had 3 surgeries.. and feel the ileo will give me a better quality of life. You shouldn't have to suffer like this and there are probably a lot of options available to you. Are you in the UK? and what tests have you had done so far? Welcome anyway and hope you find some support here - it's a great group of people. Sarah x

Hi Emma.. been thinking about you overnight and just wondered a few things. Why did your gastro not suggest prucalopride? were they just not aware of it?

Also have you ever been tested for SIBO or SBBO.. basically bacterial overgrowth syndrome. It's probably unlikely, and mostly the symptoms are diahorrea not constipation, but a small number of people present with constipation. It can be triggered by a bug or food poisoning etc.. which is what made me think of it. They thought I had it for a while too and the treatment is antibiotics on and off for a while. It might be worth asking for a test - I think you can have a breath test (may not do it in NI?). It certainly doesn't sound like UC though...

Also have you seen a surgeon yet ? or had a second opinion from another gastro? I think I'd be asking to see a surgeon at this point. I don't think you can think about what your options might be (ileo, total colectomy, J pouch etc) if you haven't had a surgical consult.

If you're still retaining markers from a transit test whilst on prucalopride things must be very slow. You poor thing!!!

I totally get how you feel. I'm exactly the same. My diet is all low residue and low fibre and sometimes go onto liquids. Some nights I can't sleep I'm so uncomfortable and mostly I look about 7 months pregnant. Like you I've done the rounds of laxatives .. I was at the point of taking 15 sennacot all in one dose and it would still take 24 hours before anthyhing happened. Even now whislt taking this medication, I can do 4 sachets of movicol plus 4 senna all in one dose and nothing!!!

I now do a picolax treatment once every 8-10 days and that does seem to help, even though it wipes me out for a day or so. Like you I feel utterly miserable.. the bloating, distention and nausea is a nightmare and I can't focus on work properly.

Bizzarely I'm having a few 'okayish' days which confuses me further, but I know it wont' be long before things get worse again. I'm seeing my surgeon on Friday to make some decisions.

All I know is that you have to keep pushing, getting appointments with doctors, second opinions and making them understand how miserable this is. Don't just suffer.. there will be a solution to this for you!
Sarah x

hello,

is it so nice to read that others having the same problems as me. i feel like a leper at times always discussing my bowel habits but it makes me so miserable and uncomfortable and its taking control of my life. so thank you guys for sharing. i know i am not alone.

i started prucalopride yesterday.. and omg!! i took it at 3.30 pm.. and began an evening shift at 4.20pm. i started to feel quite weird!! headache nauseaus.. dizzy and hot!i thought it was because i needed to go!! but when i got home i read the side effects of this drug..

like many of you i have had problems for a long time. getting worse after a traumatic relationship breakup and 3rd child. i tried various softners, bulking agents, high fibre diets. i even joined a gym and started to swim. 1 year on i have lost 2 stone and my bowel problem has actually got worse..i visited my gp.. who referred me for a sigmoid. what a painful procedure this was. they queried ulcerative colitis.. the biopsy showed nothing. then it was diverticulitis, ibs.. but mothing has ever been confirmed.

i re visited my consultant. i explained that it is affecting my life to the point of my relationship having problems.. my children saying i smell... well after 6 dulcolax laxatives on alternate days who wouldnt!.. my job.. as a home care support its difficult to find a toilet...

i suppose i will have to take these tablets and see what happens. i have asked for a dietician appointment as i find a high fibre diet does not help.

thanks for allowing me to talk about this. what a fantastic site. i wish you all well.

emma

What I find quite strange reading all the posts on this thread is that none of you it seems have been tested for Obstructed Defecation Syndrome by way of a Defecating Proctogram. It seems obvious to me that this should be ruled out before doing any surgery or taking any drugs.

Hi Everyone, i'm so glad i read all your threads. I'm 42 with 3 children and have suffered for over 10 years with IBS. I too have been asked so many times if i'm pregnant!!. I have tried everything you can imagine to empty my bowels and basicially learned to live with it!. Last year i started to get severe pain under my right rib!, my doctor was bloody useless, kept fobbing me off with gastric pills! After 6 visits and my Husband getting crapty with him he finally referred me to a specialist. They thought it was my Gallstones!, i have had 2 CT scans, gallbladder funtion test, 2 ultrasounds and an endoscopy! All clear!!. The pain now has worsened and spread to the under the right rib! I got a second opinion and he was fab, he said he thinks they are barking up the wrong tree and its my bowels!. In the end i paid to see a private bowel specialist last tuesday, he was lovely and was horrified at how full of poo! i was. He said my colon doesn't work and that parts of my large intestine are blocked! I'm not convinced, i feel like my intestine is cramped and inlarged, if i sit down it feels like i did when i was pregnant and pushes up on my ribs!, its also has a throbbing burning feeling!, does any of you guys have this feeling???. I have gone on a lactose free diet which i highly recommend to all of you, as us peeps with crappy(pardon the pun) digestive systems cannot tollerate lactose!, in 3 days the burning has lifted! However, he seemed adamant he was right and has prescribed me Prucalopride!!!!, after reading this i'm really not sure!!, does it work?????? Lee x

Sorry to drag up an old thread, but I've been furiously googling prucalopride for the past few days, and everyone's posts have been really informative.

I'm 23 and have had issues with constipation since birth. I've never been able to use the toilet without stimulant laxatives, despite insistence that improvements in diet and exercise should be all I need (like many of you, high-fibre foods make me feel bloated and ill). I was on varying doses of Senokot from the ages of 3 to 19, when upwards of 10 tablets in a single dose had no effect. Since then, I've been on 10-15mg of Bisacodyl (Dulcolax) and either 2 sachets of Movicol or 300mg Docusate every 3-4 days, though both of these tend to make me vomit if I take them over a prolonged period.

Recently, bisacodyl has stopped working for me - 10mg has no effect, whilst 15mg makes me pass water but seemingly little else. I'm incredibly bloated, and can't remember the last time I feel I've properly opened my bowels. The last time I saw my doctor (2010), docusate was the last bid option before surgery, but I found out about prucalopride over the weekend, and I'm incredibly interested. I'm disappointed to see that it seems to wear off after 5 weeks for most, but at the moment, I'm willing to try anything to keep me away from surgery for a few years (I'm about to start training as a nurse).

For what it's worth, I've self-diagnosed with colonic dysmotility due to the fact that I've always been dependent on stimulant laxatives. Doctors have tried telling me I have IBS, but usually they haven't read my mountain of notes! The last specialist I saw simply diagnosed me with chronic constipation and left me to self-medicate (it was nice to be trusted with my own body, instead of being told to drink 2l of water a day and eat more veg!)

Do you guys think I'll see any improvement with prucalopride, or am I wasting my time? I really need a long-term solution, at least until I'm qualified and have more time to worry about my stupid body. At the very least, it's nice to have found a forum with people with similar experiences, I think I'll be sticking around!

I am brand new to this forum. I can't believe I haven't found it before!!

I am 24 and live in Australia. I have had severe abdominal pain, nausea, constipation and other symptoms for the last 3 years. I have been so unwell I have not been able to work at all in that time. I have had so many tests it is unbelievable. My doctors haven't diagnosed me yet. They just say I have 'dysmotility' because they can't work it out.

I had an ileostomy formed in may 2010. I had problems from day one. The main point I want to make about them is, if you and your doctors are considering forming an ileostomy or colostomy ASK THEM TO MAKE IT REVERSIBLE!!!!!!!!! If you do not have a condition like cancer, where parts of your body need to be removed to help you heal, then it is actually possible to form an ileostomy and just disconnect your large intestine. The surgeons can just leave it inside your abdomen. I was only told this by a surgeon in my small town. None of the big city doctors even mentioned it before they did my surgery. The large bowel doesn't die or disintergrate or cause infection or anything if it is left inside you and prepared properly. They keep it connected to your normal blood supply. The reason I recommend you leave it in (not that I am a doctor), is that you never know if you will need your ileostomy reversed (like I did) or if they will develop techniques or drugs later on to help your condition. Also a friend of mine who had an ileostomy needed her large intestine later on for "spare parts" for a subsequent surgery but had already had it removed.

Hope that is a little bit helpful to anyone considering surgery.