Fatigue is a major problem for me. I found a good article that describes it well and offers coping techniques. I've posted this on the RA forum but it applies across the board for systemic AI's including lupus (which is mentioned in the article). Hope I'm not breaking rules by supplying the link to the article here as well - apologies, moderators, if so. Just thought it might be helpful in both places.
http://www.hss.edu/conditions_mastering-impact-fatigue-ra.asp
Lucy