I honestly do not feel that what you are experiencing is from plaquenil itself. I urge you to read the side effects of the medicine, this medication has been around a long time, there is nothing that states it causes depression and definitely not bipolar. Perhaps what you are experiencing is simply coming to terms that you have lupus, I'm not sure. If you're feeling off or depressed this really should be discussed with your doctor.
www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0010621/?report=details#side_effects[Edited to make link active.]
Post Edited By Moderator (Lynnwood) : 9/6/2016 8:24:33 AM (GMT-6)