The one that works for almost everyone is described in our "New to Lyme?" thread. If you haven't read through that yet, please do - it's full of a lot of important information.
If you just need a reminder of what it said - it's Epsom Salts and peroxide used either in a foot soak - especially helpful if you have trouble detoxing - or in a full bath soak. Dry skin brushing helps the skin to be ready to detox all that it can, and drinking at least 64 ounces (or more) of pure water daily will help flush toxins out of your kidneys, liver and bladder.
None of the detoxing is a magic pill type of solution - you have to lower the amount of toxins in your body, so it takes each of us a different amount of time to start really feeling the effects, but they are still working none-the-less.
For those that need extra help, I suggest that they look into Dr. David Jernigan's Anti tox formulas. Dr. Jernigan owns and runs the Hansa Center in Kansas, and has a Holistic practice that treats people with Lyme and other issues. His site can be found here:
hansacenter.com/store/ (From time to time you can also enter into a live chat with some of the staff at Hansa!)