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MTHFR gene mutation may increase cytokine release!!!

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Posted 2/6/2013 4:56 AM (GMT 0)
Hey all,

So my daughter got back her blood work today and she has the MTHFR 677 and a12898c gene mutation. I am still waiting for my results, but given that I do great w/ methyl b12 and b6, I have a feeling I have these issues as well. Needless to say, I have been researching up a storm, and I came across the most interesting info!

Increased Hcy or homocysteine levels, which can be due to the c677t mutation can cause a cytokine cascade! Ever since I had that cytokine storm in December, I was questioning why and how it happened.. Maybe this was it!. Need to watch those HCY levels...

Samantha

Posted 2/6/2013 1:14 PM (GMT 0)
Thanks so much for sharing this info!! I find it incredibly interesting!

I'm hoping that one day, I will be in a position to have a bunch of testing done -just for my own info now - so that I'll know what's been happening with me as well.
Posted 2/20/2013 1:32 AM (GMT 0)
HI,
What are you doing now? Did your dr. put you on anything for this?
Is it reversible? I just found out that I have MTHFR. What does this mean?

I have Lyme, Babesia Duncani... : (
Posted 2/20/2013 2:21 AM (GMT 0)
If I tested normal for B12 does that mean that I most likely do Not have this mutation?? Just curious bc it seems like a lot of people that have it have B12 deficiency.
Posted 2/20/2013 2:22 AM (GMT 0)
I just for some test results for this too, but all I can see is that it says MTHFR mutation heterozygous for C, idk if this is good or bad? It's all a little over my head. I'm trying to research but I'm in the midst of a herx that's refusing to let me comprehend any of this, lol!
Posted 2/20/2013 2:41 AM (GMT 0)
I'm new to posting, I hope I am doing this correctly.... if not I'm sorry.
I tested normal for B12 a few months ago and a year ago. I was completely surprised to hear I have MTHFR. My internal medicine doctor was convinced I had connective tissue disorder, did major blood work for that, and it came back negative, ANA dropped from 1:160 (a year ago) to 1:140. That made me feel better.
Do either of you have Babesia Duncani with Lyme? That seems to be my biggest problem, I can't shake it. I am currently taking Coartem for three days with Doxy, and then switching over to Artemisinin for eleven and repeating for 2 months. Any suggestions?
Did Lyme/Bab.D. cause this mutation?
Posted 2/20/2013 2:48 AM (GMT 0)
I have the mthfr gene, is that related to connective tissue damage?
Posted 2/20/2013 2:50 AM (GMT 0)
I'm not sure if it is related to connective tissue disease, but it can cause it along with many other issues... wish I knew more about it.

Just found this site on it... interesting
https://sites.google.com/site/drjoneskids/mthfr

Post Edited (lymearita) : 2/19/2013 7:53:43 PM (GMT-7)

Posted 2/20/2013 5:01 AM (GMT 0)
mthfr.net has a wealth of information about these gene mutations.

Having MTHFR gene mutations does not necessarily change one's B12 blood level, and in fact may cause the B12 and Folate blood levels to be higher than normal.

This is because MTHFR gene mutations impair the body's ability to convert folic acid to methyl-folate (biologically active folate), and to then use this methyl-folate and vitamin B12 in the production of glutathione.

Glutathione is a most important substance for everyone, and especially for those of us with Lyme/coinfections. Glutathione is a strong antioxidant (protects cells from oxygen free radical damage; free radicals are generated as a result of normal metabolic activity in the body, and also as a result of immune system activity when it is fighting infections).

Glutathione also is needed to detoxify metabolic byproducts, heavy metals, environmental toxins, and Lyme/coinfection toxins/die-off.

Being heterozygous for 1 MTHFR gene is not as serious as being homozygous for 2 MTHFR genes, but both cases can require nutrition support - in the form of methyl-folate (5-methyltetrahydrofolate) and methyl-B12 and/or hydroxy-B12.

Heterozygous = only one of 2 copies of the gene is mutated.

Homozygous = both of the 2 copies of the gene are mutated.

There are 2 MTHFR genes, so theoretically one could have 0, 1, 2, 3, or 4 mutated genes associated with the MTHFR enzyme in the Methylation Cycle.

Again, more info can be found on mthfr.net

For more info on the Methylation Cycle, see www.heartfixer.com/AMRI-Nutrigenomics.htm
Posted 2/20/2013 5:10 AM (GMT 0)
Razzle- thank you! I realize you tried to explain this to me on my post about the MTHFR mutation, but I just couldn't grasp it at the time. Idk if its the wording in this post or if I'm just having a moment of clarity (lol), but this makes so much sense to me now. Thank you!

Btw I am blonde and willing to admit that could have something to do with it as well ;-)
Posted 2/20/2013 1:49 PM (GMT 0)
Thank you for the post... waiting to find out which one I have.

So should I take B12 sublingual or not?

Thanks again.
Posted 2/20/2013 6:04 PM (GMT 0)
With MTHFR, you can't process folic acid into folate. (There are 4 processes in the body that convert folic acid). Folic acid isn't naturally occuring in food, it is folate. Most forms of b12 are the same thing. B12 needs to be converted to Methyl b12 for our bodies to use it. For those of us with the mutation, we can't convert it. Which means our body cannot produce glutathion - an antioxident our body makes to break down ammonia and other toxins. And we all know with lyme and yeast, when they die off, it creates ammonia.

So those of us with MTHFR gene mutation, getting our b12 levels tested means nothing. Because it doesn't matter how much b12 we have in our body if we can't convert it. And actually taking b12 (unless it is methyl b12) or folic acid is dangerous. My daughter's b12 level is high...through the roof actually. B12 is water soluable - which means we excrete what we can't use. So why is my daughter's high? Because it sits in her liver, and causes inflammation and toxicity. If we can't process it, we can't rid it. Now she is on high levels of milk thistle to clean it out.

lymearita, sublingual b12 is ideal, although make sure it reads methylcobalamin. That is the active form of b12 our body uses. Even for those that don't have the gene mutation, b12 is not easily absorbed into the body unless it is taken sublingually.
Posted 2/20/2013 6:10 PM (GMT 0)
Ahhhh!! Leave it to Razzle to be able to explain this!!
Thanks Razzle!! smilewinkgrin
Posted 2/20/2013 7:57 PM (GMT 0)
Oops, Samjones! Your post tells us a lot as well! Not sure how I missed it - maybe it's because I only have one eye open from lack of sleep last night???? Hmm.

Thanks for explaining this stuff to us!! smilewinkgrin
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