New reserach paper: Ceftin+Doxy+Daptomycin achieve complete Borrelia biofilm eradication

As always, thanks mpost! Love your research capabilities!

I didn't see dosing on there. Looks like no pulse - so daily IV? Would be nice to do this without having to get a picc line. 21 days of going to get IV wouldn't be too bad.

I may consider talking to my doc today about this.

k07 said...
As always, thanks mpost! Love your research capabilities!

I didn't see dosing on there. Looks like no pulse - so daily IV? Would be nice to do this without having to get a picc line. 21 days of going to get IV wouldn't be too bad.

I may consider talking to my doc today about this.

no pulsing, daily IV with daptomycin, and two pills (ceftin and doxy).

I know this is an in vitro test, but think of the fact that before this we had nothing, not even an antibiotic combo that works in test tube. Dr Zhang & team have found a combo last year, but it involved an antibiotic that is no longer used on the US market (and probably not much in Europe either) - cefoperazone. So that combination was not really something u could use to run clinical trials. Not to mention two IV antibiotics per day.

But this new one looks good !

Anyway, im positive, things are moving in the right direction. In 2-3 years the chronically ill patients should have more treatment options, and maybe we will not need take 6m of abx. If they work well , one-two months would be enough.

happyjo said...

(Doesn't Johns Hopkins/Zhang, align with CDC?).

Check out this short interview with Dr. Zhang, he says it loud that CDC recommendation is not sufficient for chronic lyme:

/www.youtube.com/watch?v=krXSFmkwXxo

happyjo said...

Yet in the "Frontier's in Microbiology" article, Dr Zhang discusses "PTLDS." ("A rose by any other name...").

Yeah but he says one possibility is the the bacteria persists, hence this is the purpose of his study, to find better antibiotics to clear it up:

"Although the cause for PTLDS is unclear, one possibility is the presence of bacterial persisters not effectively cleared by the current Lyme antibiotics."

Dr. H from NY says in his book that over 99% of his chronically ill patients relapse when antibiotics are discontinued
www.healingwell.com/community/default.aspx?f=30&m=3577020
This is an LLMD that has treated over 25000 patients and ofc follows ILADS, so it's obvious we need better antibiotic combinations to beat this...

Dr. H is already running clinical trials with some of these antibiotics that were found by Dr Zhang last year. So it's not just politics on paper and money spent on useless research.

DaveNJ41 said...
How do these antibiotic combinations address mold toxicity, candida (which if you are taking three at one time it will most likely destroy your gut flora and cause candida to run wild, numerous co-infections, viruses, mitochondrial dysfunction, detox issues, etc? I think it's wonderful that new research is being done to help push chronic Lyme to a new research plane, but I am always very skeptical of a "magic bullet" treatment.

Bartonella, Candida, Mold, all are opportunistic. Healthy people can be Bart positive and have absolutely no symptoms. HIV/AIDS patients can have horrific bart infections.
/en.wikipedia.org/wiki/Bacillary_angiomatosis

It all comes down to the immune system. If your immune system is suppressed by Borrelia you will have problems even with Lactobacillus acidophilus, some people develop SIBO. You can also develop cancer, mutant cells are usually killed by the immune system and not grow to develop cancer.

AIDS people (before treatment was available) used to have a low life expectancy (9 years max) because of multiple types of cancer and opportunistic infections they would develop. HIV has never killed one single person with AIDS. Candida has.

Anything that grows will grow larger and out of control if there is no immune system to keep it in check.

So if u could just wipe out all Borrelia from a chronically ill person, that person's immune system will kick back in and will keep all these bugs in check. That is why they are all called co-infections. They create problems because of Borrelia.

And heavy metals, etc.... they are a problem, but we lymies are so sensitive because our immune system is on the knife's edge. Tilt it a bit more and it will break. Several sleepless nights, a small cold, too much lead or mercury, and it's already losing the battle.... So a minor obstacle becomes a huge issue.

But if u remove the cause....

Dr. H posted about the article on FB. He mentions that he is in the process of evaluating the use of oral generic drugs with persister properties and the initial statistical data is encouraging.

/www.facebook.com/drrichardhorowitz/

This is fascinating and encouraging. I'd volunteer to be a human guinea pig right now. I wonder if my LLMD would consider this?

Thanks for posting. This is an in vitro study, not in vivo. It makes a huge difference.

k07 said...
Any of you smarty pants know what drugs are used for mycobacterium infections? From what I could find online it looks like the same drugs already used for Lyme & Co. Looked like Rifampin and Rifabutin were most successful in treating mycobacterium.

Yes, it's dapsone (diaminodiphenyl sulfone) and pyrazinamide.

I think Dr. H is trying to capitalize on Dr. Zhang's experience with TB persister drugs, he has had some important papers on the topic before the lyme research ones, more specifically on pyrazinamide and isoniazid.

Read more about Dr. H's clinical trials with TB persisters here
lymewhisperer.com/2015/12/13/kripalu-closing-in-on-the-8/

I also heard Dr. H. during a recent lyme conference saying patients on pyrazinamide have had "the herx of their lives" on it, but i can't find the recording, ill share it if i do.

Anyway, im 99% it's a combination of doxy / ceftin / pyrazinamide, so pyrazinamide as a replacement for the expensive/difficult IV daptomycin as persister drug.

Post Edited (mpost) : 2/11/2016 10:26:58 PM (GMT-7)

Never heard of pyrazinamide. Is it a safer drug?

There u go, for the unfaithful, i found the exact part when Dr. H. is talking about these trials he is running with pyrazinamide/etc.

Watch this from the pinned time /www.youtube.com/watch?v=uj0H3T9HMeQ&feature=youtu.be&t=3626

So this is not just an "in-vitro effort". They'll publish something this year about how this works on people.

That was great mpost. I never tire of listening to dr.h. I have an apt with his clinic at the end of March if I can afford it! Worst case I push it to the summer.

Actually one member of the russian Lyme community tried original combination
cefoperazone+doxy+daptomycin for 6 weeks (if I recall correctly)
It bring improvement in symptoms that plateaued after 4 weeks of therapy and although improved he havent cured by any means.