Mepron - Side Effect, Herx, or MCAD?????

Hi everyone,

I started Mepron the beginning of February. I started very slow, only 1/4 teaspoon twice a day. Wait a couple of days and kept slowly increasing until now. Saturday 13,I got up to one and a half teaspoons twice daily (7.5ml twice daily). Last week, I started to get pain in my right arm. It felt like when you hit your funny bone. This only happened a couple of times.

Wednesday, February 17 (still at one and half teaspoon Mepron) started my period, off balance, air hunger. Thursday 18, kept saying the word "Then" over and over again out loud, I couldn't stop. Then I lost my ability to Say a single word. Friday 19, felt very depressed and empty inside. I felt like I could cry. Air hunger was also increasing during this time.

Saturday 20, woke up in the morning with excruciating pain. The pain is from my spine to my shoulder. It radiates the upper right quarter of my back. It sometimes hurts to breathe if I move wrong or cough. The pain also radiates all the way down my right arm to my fingertips. Felt very depressed and emotional also. The pain is also in both of my biceps, but not as severe as my back. Loss of appetite. Headache worse than my normal daily headaches.

Sunday 21, still a lot of constant pain. I still am unable to talk. I decided to stop all antibiotics for today.

I read some of the side effects of Mepron: trouble talking (This is Not the first time this has happened to me), not hungry, muscle pain, depression, headache.

about once a month, I have an episode where I loose my ability to talk. This has happened for the last 9 months and has become "normal " for me. It doesn't cycle with my period, and it doesn't matter what type of antibiotics combination I am on.


Since I Herx on anything and everything, My LLMD thinks that I might have Mast Cell Activation Disorder (MCAD).
She prescribed me: Zantac (150 mg) twice daily, Hydroxyzine (100 mg) twice daily, and Singulair (Montelukast) (10 mg) at bed time.

I just started these new medications today, so I hope that they work!!!

And YES, I am detoxing Daily!! I use a lot of methods for detoxing.

So, I guess I am also wondering what other people's experience with Mepron was like?? Did anyone else have severe muscle issues? Or very depressed and emotional?

Thank You!!

Little Bear - I feel so bad for you - suffering like that.

i can emphasize with the spine to shoulder pain - down the arm to the fingers...That is my worst symptom.
Does anything help to relieve it? I used to use ice packs...but I was concerned about CRPS - and you shouldn't use ice if you have that...so switched to just cold cloths. They also worked to give me some relief.

(I'm not saying you have CRPS - I didn't know I had Lyme at the time..so thought that's what it might be)
That was when I had bad nerve pain.

I don't have any experience with Mepron.

I hope you get some relief soon

Sending hugs to you.

Hi Girlie!-

Thank you for your response! I greatly appreciate it!

Yesterday, I tried heat on my back and my husband gently massaged the area. It is strange, it will feel like it gets a little better for an hour. Then BAM!!! If I move wrong, it hurts so bad that if I try to move my arm, I grunt in pain. And sometimes it hurts to breathe or cough.

I am so sorry that you are also dealing with this. :(

I hope that we both can find some relief!! :)

Thank you for the hugs and support. It means a lot!

On, Little Bear!! So sorry you're having these issues!!

I'm glad you have something new to try and I hope it works!!!

And, I'm sure those who took/are taking Mepron will be along to share.

Onward and upward ;)

I too would begin to wonder if it's a reaction to the Mepron. It might be time for a little Mepron holiday to make sure that's not the trigger before you continue on.

Thank you: Silly Sheep, Cd, Sarah, and Traveler for all of your responses!

I decided to lower my dosage and take 1 teaspoon of Mepron twice a day.

I have pressure in my eyes, right eye sight gets blurry, a strange noise in left ear , colors look different ( like when you have a flu and fever and lights in the room look more dim). I know that these are some signs of abbesia.

I would like to write more. but my "Alzheimer's" brain won't let me.

Thank You!!

That's the base dose but some LLMDs prescribe more. 2tsp twice daily isn't uncommon

I take mepron, 2 tsp twice daily. Ugh, it's intense. I wonder if that's why I am having so much trouble talking to other people. To myself and my husband I'm fine but to other people , like when there is even the tiniest touch of social stress, I lose my articulation, I make sense but it takes forever and a lot of explaining and gesticulating to get my point out and most of the time I end by saying..."never mind, I don't know what I'm trying to say."

Little Bear, do you also herx on supplements? I had such a severe herxes on 25 mg of minocycline every second day that I could only take it for about 5 days....severely depressed (wanted to end it), pain and more damage in my back, insomnia, etc. The flares take forever to settle, even with lots of detoxing.

That combo probably wouldn't work for me either. I have constipation already and have to take 2 stool softeners, restoralax and 3 heaping T of ground flax seed for breakfast daily.

Hi dmw52!-

I feel like I herx on everything, except the A-Inflam (Byron White herbal drops) that I am taking. This is supposed to get the inflammation down in my body.

I tested positive for Lyme disease back in January 2015. I think that I have had Lyme and co- infections that went misdiagnosed for 27 years. I have so many symptoms daily and I detox daily with multiple ways.

I was tested for MTHFR gene mutation and found out that I am Homozygous A1298C.

Did you ever test for gene mutations? Sometimes these can greatly affect the healing process of Lyme and co's.

Best Wishes!

Hi Little Bear,

I did the 23 and me testing. I don't have the MTHFR deficit but I have a lot of others. I would be interested in hearing which dr you go to. My email address is on my profile. It sounds like he/she is very good and looking at thinking of why you are having such severe herxes. I am currently taking zantac twice a day and claritin 3 times a day. I just started the zantac so too soon to comment. Do you have breathing difficulty when you herx?

Take care.

Little Bear, I have mold toxins...tested by Real Time Lab. I can't tolerate the treatment to remove the mold toxins due to MCAD and the severe reactions.

I have been taking zantac and desloratadine. I just started ketotifen, but too soon to say if it is doing anything.

Please let me know if you find something that helps. I am in Canada and don't know who to go to for treatment in the US.

My chest muscles get so tight when I herx that they move my heart slightly out of place and I feel every beat of my heart. The osteopath is able to help with this.

Wow, I feel like I'm having the same issues with Mepron! I haven't totally lost my ability to say words, but I find myself writing things backwards, repeating myself, forgetting what I was about to say.

But that is manageable...what is NOT is the unrelenting fatigue that seems to be growing with each day I take this. I am so tired sometimes it feels like I'm too tired to breathe. I used to be able to walk up a small hill in my neighborhood every day or so when i was treating just lyme and when I took a month break from the abx to recover from herxing and build up my immune system, but now I feel like I can hardly function at all.

Ever since day 5 or so of Mepron / zithromax (i'm on day 8 now), I've been even dizzier than before, headaches never ending, pressure behind my eyes, unsteady walking, too weak to walk anywhere really (forget showering standing up, or even every day). I feel a deep tremor / pulsing / illness throughout my body whenever I lie still (which is why I shift around a lot in the armchair that has become my home)

Little Bear - have you gotten any relief from your horrible mepron side effects or did you just give it up entirely?

Del Oeste - have your post mepron symptoms resolved since your last post in May? I feel like I may have done the same thing...drive the lyme and babesia out of hiding where they are now at new levels and not going back to what i thought was my baseline.

If anyone has updates or advice on this I'd really appreciate. I don't want to stop the drug prematurely, and of course I want to kill babesia, but I don't want to kill myself / ruin my body in the process!!