Science Stuff

My wife and daughter won't be in for a little while so I'm home alone and thought I'd post some random notes I've taken. Some folks like to see them, others maybe not so much.

-Our body can't make Vitamin E.
-A decrease in Vitamin E causes aging.
-Vitamin E is part of superoxide dis mutase, catalase, glutahione peroxidase, and selenium. Gray hair is a result of a failure of one or more of these components.
-Vitamin B2 (riboflavin) supplies oxygen to our body tissues.
-Purines stimulate Vitamin B over production. (Hypermethylators)
-Glycine can increase the growth of candida.
-L-glutamate, L-aspartate, and L-asparagine increase the level of Vitamin B2.
-A transition metal acts as a catalyst for ammonia production. (Maybe this is why we become deficient.)
-Ammonia is converted to nitric acid and this is exothermic. (Cause us to be hot.) Ring a bell babesia folks?
-Patients with H. pylori have decreased manganese and produce ketones.
-Signs of elevated acetylcholine are incontinence, muscle twitching, blurred vision, and unusual pupil diameter.

I've got page after page of stuff like this.

awesome notes!

Keep posting! Thanks.

Good stuff lymie mom x 2.

Pirouette, I am definitely unique. I'm not sure that is a good thing sometimes.

Some comments on what was posted.

Copper levels are really interesting in chronically infected patients because the liver releases more copper and polyamines increase extracellular copper transport. The liver copper levels drop, the intracellular RBC copper levels drop, but the WBC and extracellular copper levels sky rocket. We can actually test high for copper and be low. I don't think anyone should take copper continuously, but pulsed copper at the appropriate time may be beneficial. I saw benefits for 2 or 3 days, then problems after that.

When copper is high, molybdenum is low.
High sulfur and chronic yeast can both decrease molybdenum.
Alkaline foods limit copper.
BHMT8, C677T, and MTHFR03 mutations have major predisposition for H pylori and decreased copper levels.
Decreased copper levels lead to increased histamine production.
People with increased histamines need to eat cherries.
If you have CGAT or SHMT2 mutations, your glycine levels will be greatly affected.
MTRR mutations lead to mineral depletion.

Iron is the key to most infections. It makes pathogens virulent. I'm at a loss as to how to deal with that. Borrelia appears to utilize magnesium instead.

GH & LM2~ interesting (GH-does your daughter roll her eyes at you when you spout about vitamins & nutrition? Ha-they are lucky to have someone so knowledgeable!).

And LM2- 18 tabs-yipes-u are organized!

So best brand/type/source of Vit B,C & E from you smart folks?

Georgia Hunter said...
Pretty much, but my wife is a pharmacist also so she's used to our talks. My daughter is 13 and doesn't want anything to do with medicine. She wants to be a Constitutional lawyer. She loves to read and at age 12, she made a 29 on the ACT in reading. I didn't make that high in reading when I was a senior.

Wow! That's amazing! Congrats on having such a fantastic reader!

Happyjo-

Food source of vit C is best, kiwi is really high but you can also supplement with vit c caps with bioflavanoids. I take anywhere from 1k-5k vit c at a time for the antioxidants and to help detox. I muscle tested that my liver loves high vit C.

For my Bs- I use either Thorne or Pure Encapsultion's Multi Bs. Also I like fermented cod liver oil, also helps with vit D and A.

For vitamin E- nuts and seeds are a good choice. You can also break open the Vit capsules and use them on your skin. It can help restore collagen too.

Thanks guys!

GH-impressive! Teen girls can have such a "smart mouth" on 'em so your daughter now aligning her IQ & natural born glib while using law references--watch out!

Krimpet said...
GH-if you don't mind me asking, what is your profession? When I read your posts, they scream, researcher.

I'm a pharmacist but was a heavy science guy when in high school. The scientific method runs rapidly through my veins. My science project my senior year won at the city, county, region, and state science fairs, and I even got to go to the International Science and Engineering Fair in San Juan, Puerto Rico. It won numerous awards and two scholarships.

happyjo, I'm proud to say my daughter is much smarter than I was. Co-infections have taken their toll on me now and I can tell I'm on the downhill slide. My daughter is one of the best arguers I've ever seen. I have trouble winning arguments with her now and she's not even close to being grown. She really is something special.

When she was 6 or 7, I was driving her to her grandmother's house and she was reading one of her books. I noticed she was reading really fast so I subtlety timed how long it took her to read one page. When she turned the page, I asked her to count the words on the page she just read. When I calculated it up, it was over 650 words a minute. She attends a private school and has had the highest average in her grade every year since the 1st grade. She's had 100 averages on several report cards. She also has epilepsy that has been controlled for 10 years now.

Great question Tommy08. Like most things in our body, there are multiple issues that cause our BH4 levels drop. We must examine the precursors that make BH4 and what might recycle BH4. Genes and diet effect both the precursors and our recycling ability. Eating more leafy greens increases folate levels which increases BH4 production.

www.sciencedirect.com/science/article/pii/0165032789900621

When we have infections, (especially fungal/yeasts) our phenylalanine excretion level goes way up. There are tests for this. It's been shown that high phenylalanine levels affect blood levels of biopterin. If it's in the blood, it's not in the cells where it needs to be to make BH4. Reduce the infection and reduce phenylalanine intake and this should help make BH4. Phenylalanine is in milk, eggs, and meat.

www.sciencedirect.com/science/article/pii/000989819390139U

Sulfa drugs like Septra DS or Bactrim DS reduce BH4 levels.

Here is a quote from a reference: Tetrahydrobiopterin biosynthesis within cultured dopamine neurons of the hypothalamus and mesencephalon thus appears to be regulated by a cAMP-dependent mechanism involving enhanced gene expression of enzyme(s) involved in cofactor biosynthesis.

I find this interesting since the polyamines bind cAMP and directly affect this pathway. That's a much longer and deeper discussion that would take more research. Element wise, a decrease in body calcium, magnesium, and/or molybdenum can affect BH4 levels. They do it in differing manors which are too lengthy to discuss.

IMO, the best way to increase BH4 levels is by diet. I know it's not popular or fun, but it has been effective for me and many others who choose to adhere to the strict guidelines of the Wahls Diet. I ate it with over 90% compliance for 1 month and saw a drastic change in health. Research into why it improves health did not turn up any direct references, but my opinion based on multiple inferences from references is as follows. The Wahls Diet decreases phenylalanine intake, it increases antioxidant intake, it increases folate intake, it increases mineral levels (polyvalent cations) and it provides a source of flavins from the bioflavinoid intake. BH4 is a flavin. All of these things increase BH4 levels.

I think when we become sick, our body becomes overburdened because it doesn't have enough "raw materials" to function like it did in the past. Aging is the same. So much processing is going on that we become deficient in the chemical moieties that we need. I believe this is why eating polyphenols helps me. It is very complicated and much more to it than I know, but looking at it simply, 2 + 2 = 4. It always has and it always will. Our body works on the same principle but after we become sick, we're trying to make 2 + 1 = 4 and it just doesn't work. We just need to add a little bit to it and it will work like it's supposed to.

And what is sobering is the subhuman behavior of the medical, pharmaceutical and food industry in this country .

I think for those of us who have these issues, it comes at a time when we can make a change - for ourselves and for anyone within earshot ..... The people on these message boards have more fight in them than any other group I have experienced, and that fight have been brought out not only because we fight for our own health, but we are fighting an established, corrupt monster that calls itself "healthcare" when really, what it is, is a sickness industry ..

We must continue and persevere

Traveler said...

Georgia Hunter said...
Borrelia appears to utilize magnesium instead.

GH - Don't you mean manganese, not magnesium?

Yes, but at least I got that it started with an "M".

That's the best I can do that early in the morning. lol

Traveler said...
I figured you knew that it was manganese, but wanted to clarify.

Maybe you need more coffee (or tea or whatever) in the am?? My non-coffee coffee only goes so far to help my brain in the early am!!

I don't drink caffeine. Around 20 years ago, I would take my lunch and hunt all day long. My headaches were so bad that I'd have to climb down and go into town to try to get relief. I discovered that if I drank a Coke, it would help. After doing this a few times, I concluded that I was addicted to caffeine and was having caffeine withdrawal headaches. I quit caffeine cold turkey and haven't had those severe headaches since. If I do eat a piece of cake or something that has caffeine in it, I get a similar headache just not as bad. Now I know that I have mutations in BHMT2, BHMT4, and BHMT8. This would contribute to this problem.

On a side note, I don't like clam chowder but my Dad loved it. In honor of him, I ate a small bowl last night. I'll be investigating what was in it because I slept last night like I had taken 10g of glycine. I don't know if it was but it sure had a definite effect.

PeteZa said...
Clam chowder - New England? I would think that would be the carbs - potatoes, cream, flour.

I love how you write and I am proud of your daughter too. She sounds like a terrific kid and I am so glad you are embracing her spirit by focusing her arguments in a constructive way. I like seeing born spirits unbroken.

The Wahl's diet is pretty paleo and I love it. In our house the brighter the veggie, the better. But I do love orange beets over the dark red ones. But we found these great sweet potatoes (japanese sweet potatoes) that are bright red inside. Thick skins, but we eat it anyway.

I think you're on the right track when it comes to a paleo diet. Most people think eating paleo means eating meat every meal and that's not how the paleo peoples ate. They ate a lot of tubers as you are and ate meat when they could get it. Not having bows or arrows, they only ate animal protein a couple times a week at best and then it was mostly small game. Mollusks played a big role in their protein intake and secondary was fish. Greens and vegetables played much more of a role on a daily basis.