I have graciously been allowed time to recover from a long two weeks by the other mods - so I took advantage of that time and did some looking into P. aeruginosa. So, if you don't mind, I'll list some of the links I came across in an effort to hopefully find information you don't already know about
. I hope. Not knowing what you may have already read, I will likely be posting at least some information that you have already read. Sorry about
that! I hope that there is at least some new information for you!
First of all, I keep reading over and over again that P.a. is a fairly aggressive biofilm builder:
iai.asm.org/content/80/8/2601 "Chronic infections with Pseudomonas aeruginosa persist because the bacterium forms biofilms that are tolerant to antibiotic treatment and the host immune response."
"Wild-type P. aeruginosa developed biofilms within 1 day that trapped and caused visible cavities in polymorphonuclear leukocytes (PMNs)."
"Pseudomonas aeruginosa is a bacteria that is a profound biofilm former."
www.betterhealthguy.com/physician-s-round-table-2012 This is why it's abx resistant partly. Lyme also utilizes biofilms, so they are in this together. My suggestion would be to treat for biofilms, but not until you are ready to treat for everything that may be contained inside of them. We sure don't want all those harmful bacteria just running loose in your body causing all manner of chaos!
www.ncbi.nlm.nih.gov/pubmed/9801351" the effects of treatment with the Chinese herbal medicine ginseng on blood polymorphonuclear leukocyte (PMN) chemiluminescence and serum specific antibody responses were studied in a rat model of chronic P. aeruginosa pneumonia mimicking CF. An aqueous extract of ginseng was administered by subcutaneous injection at a dosage of 25 mg/kg of body weight/day for 2 weeks. Saline was used as a control. Two weeks after the start of ginseng treatment, significantly increased PMN chemiluminescence (P </= 0. 001) and a decreased level in serum of immunoglobulin G (IgG) against P. aeruginosa (P < 0.05) were found."
"These results suggest that ginseng treatment leads to an activation of PMNs and modulation of the IgG response to P. aeruginosa, enhancing the bacterial clearance and thereby reducing the formation of immune complexes, resulting in a milder lung pathology. The changes in IgG1 and IgG2a subclasses indicate a possible shift from a Th-2-like to a Th-1-like response. These findings indicate that the therapeutic effects of ginseng may be related to activation of a Th-1 type of cellular immunity and down-regulation of humoral immunity."
This is a fairly long thread from another forum that talks about
having P.a., trying to diagnose and treat it:
lymebusters.proboards.com/thread/12521/pseudomonas-aeruginosa"Use of β-lactamase inhibitors such as sulbactam has been advised in combination with antibiotics to enhance antimicrobial action even in the presence of a certain level of resistance. Combination therapy after rigorous antimicrobial susceptibility testing has been found to be the best course of action in the treatment of multidrug-resistant P. aeruginosa. Some next-generation antibiotics that are reported as being active against P. aeruginosa include doripenem, ceftobiprole, and ceftaroline. However, these require more clinical trials for standardization. Therefore, research for the discovery of new antibiotics and drugs against P. aeruginosa is very much needed. Antibiotics that may have activity against P. aeruginosa include:
aminoglycosides (gentamicin, amikacin, tobramycin, but not kanamycin)
quinolones (ciprofloxacin, levofloxacin, but not moxifloxacin)
cephalosporins (ceftazidime, cefepime, cefoperazone, cefpirome, ceftobiprole, but not cefuroxime, cefotaxime, or ceftriaxone)
antipseudomonal penicillins: carboxypenicillins (carbenicillin and ticarcillin), and ureid
openicillins (mezlocillin, azlocillin, and piperacillin). P. aeruginosa is intrinsically resistant to all other penicillins.
carbapenems (mer
openem, imipenem, doripenem, but not ertapenem)
polymyxins (polymyxin B and colistin)[43]
monobactams (aztreonam)"
/en.wikipedia.org/wiki/Pseudomonas_aeruginosa#TreatmentI don't usually use Wikipedia as a source for information for treatments, but I do use it to look for more leads and thought maybe you could use this information for ideas.
"Pseudomonal infections are increasingly resistant to certain antibiotics, and the organism may acquire resistance during therapy. Two agents from different classes should be used when the risk of antibiotic resistance is high (eg, in severe sepsis, septicemia, and inpatient neutr
openia).
Pseudomonas infection can be treated with a combination of an antipseudomonal beta-lactam (eg, penicillin or cephalosporin) and an aminoglycoside. Carbapenems (eg, imipenem, mer
openem) with antipseudomonal quinolones may be used in conjunction with an aminoglycoside. With the exception of cases involving febrile patients with neutr
openia, in whom monotherapy with ceftazidime or a carbapenem (eg, imipenem, mer
openem) is used, a 2-drug regimen is recommended."
emedicine.medscape.com/article/226748-medicationI do hope that you can find some useful information in this. If you would like to direct me to help you find even more information, I would definitely appreciate it. No need to keep posting up the information you already know!