Suppressed B Cells? Anyone have this?

I was told by one immunologist that the reason I don't seem to get colds/flu very often despite low B-Cells, Low T-Cells and low NK cells is that actually my immune system has given up fighting or is unable to mount a response. So I might very well be infected with a cold bug, but can't fight back enough to have symptoms. It sux to have immune deficiency.

Razzle said...
I was told by one immunologist that the reason I don't seem to get colds/flu very often despite low B-Cells, Low T-Cells and low NK cells is that actually my immune system has given up fighting or is unable to mount a response. So I might very well be infected with a cold bug, but can't fight back enough to have symptoms. It sux to have immune deficiency.

i think i pasted this link a thousand times on this forum, it's a very important find:

journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004976

"
Furthermore, influenza immunization administered at the time of Borrelia infection also failed to induce robust antibody responses, dramatically reducing the protective antiviral capacity of the humoral response. Collectively, these studies show that B. burgdorferi-infection results in targeted and temporary immunosuppression of the host and bring new insight into the mechanisms underlying the failure to develop long-term immunity to this emerging disease threat.
"

it is all because of those darn persisters, they hide in the tissues and produce chemicals that interfere with B-T cell signaling and that's what's causing the immunosupression. The more peristers u have the sicker u are.

Then when Dr. H from NY gives dapsone to these patients they have horrific herxes because why ? these persisters are so widespread and they start dying and slowly they recover their life back. So it's a reversible condition, the problem is the lack of medication to kill the bug. The immune system recovers from AIDS, it can recover from lyme...

Worth watching:
/youtu.be/6kn-ieUEO7Y?t=2752

That is what immune tolerance and cross tolerance is all about. It really depends on what you have. I know for me if I catch a cold it can take me out for months. Lyme creates a situation in the immune system where you no longer have the ability to mount an immune response to all kinds of things. bacteria, protozoa, fungi, viruses...etc. Most of us are sick every single day for years on end, so we are very sick all the time in an obvious way.

It has been said that one will know what group they are in within the first few months. If you improve within maybe 6 months or so then thats a good sign. If you've been trying to treat and feel better for a couple years with little to no improvement then it may be a lost cause. This is where it gets blurry, we just don't have the data to back it up because of the crime that was committed. I think most of us at some point just know intuitively which group we fall in.

It's also important to know how relapsing fever germs work. The nature of the beast is to relapse and remit. I've slowly come to the conclusion that some of the treatments we take are getting credit that they don't actually deserve. But no one really knows for sure. I know for sure that killing mycoplasma helps, which is what a lot of the treatments do. My advice is to learn about how unkillable spirochetes really are and what they really do inside the body. Its the shedding of the surface proteins that is the true driver of disease, all of the damage is done within the first week. The antibodies themselves cause serious problems, so even when our bodies try to fight it hurts us. Brain degrading enzymes are found in our spinal fluid. We get leaky gut and leaky brain.

I'm sorry, really sick right now and I feel like I'm not making sense?

IHL said...
What makes this so confusing is that we all have different pathogens, different HLAs, and differing levels of time infected. So it's not a one size fits all.

i think this study explains why this soup of pathogens exist. It's an Acquired Immune Deficiency Syndrome. What we have is an AIDS not caused by HIV and with milder outcomes. But with the same opportunistic overgrowth of pathogens.

After reading lots of papers and seeing what happens with sick lyme patients (that have little reaction when put on doxy) when they are given Dapsone - they herx like hell, i am concluding the amount of borrelia in these patients is very high, their immune suppression is high and that makes all the other germs chronic. There are many people with bartonella in the world, a study in italy showed 39% seropositivity for bartonella in cats. So almost half have it. Now if u get scratched by it, you have it too. So probably half of the population that has a pet has Bart. Yet you don't see them flocking the forum here on healingwell with lyme posts. Why ? Because Bart is opportunistic, and as long as u don't have an immune suppression going on, you are fine... Then if Borrelia comes, u're screwed.

But it is the lyme bacteria that poses the problem not bartonella, or candida. Candida is part of the normal human gut, u cannot get rid of it and you should not get rid of it because it's a symbiont. It makes u sick because your immune function is abnormally low because of Borrelia. It's Borrelia who is the great enemy, not these other creatures. They just take advantage of your state of immune suppression.

I'd say for many of these people sick, monotherapy would be enough, if it's able to clean borrelia bacteria completely sterilize the host. You should not need to treat bartonella, babesia or any other infection, your immune system will recover and take care of these. The reason LLMDs treat them all is they cannot get rid of borrelia in the first place, and they keep the other infections in check with antibiotics. Same as with AIDS, people are given antifungals and antibacterials because the immune system is compromised by a virus.

When a potent antipersister drug, maybe with fewer side effects than dapsone (which causes that really bad anemia) will emerge, all these people with chronic lyme will recover, probably they will have to take that drug for life, to prevent relapses. Just like in AIDS...

But it's a mistake to assume "oh my god i have so many infections nobody will EVER make me better." No , you have ONE infection, the others are just hanging around because it is present. Everybody has EBV, everybody has CMV, half of the population has Bartonella. Stop telling your doctors "doc i have 20 coinfections" he will think u are nuts, it's part of the reason our community is seen as half lunatic...

IHL is it possible to update your progress on dealing with MCAS ?

I do not have confirmed diagnosis but I am showing some mild symptoms that would be present in these cases. I did not have "any" symptoms at all but consumption of 3000 IUs of Vit D made lyme like/ MCAS appear. They are currently mild and I really pray to God that I normalize.

I have reactivated HSV-1, CMV, Varicella Zoster, Coxsackie, Echo virus, HHV-6, Rubella Virus. Thankfully, i don't have EBV, as i was evaluated by my LLMD and no proteins were reactivated on any of the 5 or 6 proteins the WB for EBV has. So, hopefully, no autoimmune responses.

The only thing that i might have daily that resembles a cold or a flu is sneezing up to 8-10 times a day. All my symptoms are still neuro lyme related and coinfections.