WHY CANT MY BODY RETAIN MAGNESIUM? A detailed look at Mg.
RDA 400 mg/day is the bare minimum necessary to avoid severe consequences.
Wide array of diseases and symptoms of magnesium deficiency have to do with the fact that approximately 99% of your body’s magnesium is located in bone, muscles, and soft tissue. The other 1% of magnesium is found in plasma and red blood cells.
Soda, Caffeine, Medications, Stress, and Calcium supplements interfere with Mg absorption.
Today’s diets contain an average of ten times more calcium than magnesium.
Stress causes magnesium loss while, at the same time, getting adequate magnesium protects against stress.
It is common to see "adrenal overflow" with magnesium deficiency. You can't hold mag if you don't plug the leak & as all the studies show, if you have high adrenaline you waste magnesium in urine.
When you become ill, some of the cells in your body may become less efficient in holding on to magnesium. The cell membranes may break down, allowing more magnesium to leak out. The cell membrane pumps that pull magnesium back in may also be weakened by disease.
The end result is that disease itself can be a cause of magnesium deficiency. Since magnesium deficiency may have been one of the original causes of the disease, a vicious cycle of greater deficiency and increasingly severe disease may result.
A substantial minority of patients ... fail to improve after taking oral magnesium for months or even years. In these cases, administering magnesium by injection is necessary to overcome their medical problems."
I would suggest others have their adrenals tested as well. Perhaps they will need to plug the adrenal holes as it were before they fix the magnesium leakage problem.
Enhance storage sites for Mg. in bone and skeletal muscle by a regular and aggressive isometric and endurance exercise program.
Nutrition hacks:
Some people have also reported that if they experience the laxative affect when they first start taking a magnesium chloride product they can overcome this by starting out with small doses and then steadily increasing the dose over a two-week period so that the body can adjust. Take smaller doses of mag every few hours throughout the day divided into doses every 2 to 4 hours and when awakening during the night.
Vitamin B6 is required to absorb magnesium. Zinc can't be absorbed without B6 and you can't make vitamin D when you don't have any magnesium.
One possibility suggested by work in Norway about
10 years ago is to also increase potassium in the diet (or by supplement) along with magnesium. This dual therapy may overcome a renal "leakage" problem of magnesium.
A Taurine supplement is worth considering. taurine transports magnesium (and potassium) into cells (both these minerals should reside primarily inside rather than outside the cell). High urinary taurine usually indicates high loss of taurine rather than excess intake (blood and urine taurine levels can be tested to check this out).
Choline with magnesium supplements to enhance assimilation.
Prevent deficiency in any of the inexpensive nutrients that can prevent uptake of Mg: Copper, Boron, and Vitamin B-6. Common levels of supplementation are:
Copper 1 mg/day (Personal Note: inorganic forms may cause more harm than benefit)
Boron 3 mg/day
Vitamin B-6 38 mg/day
Mg is best given with Calcium...if not...there might be MORE spasms due to calcium blocking effect of magnesium doses (Personal note: most diets and hard water is high in calcium therefore supplementation is not recommended).
Magnesium+potassium+coenzyme Q10+aldactone thrice daily with meals for a week in patients with normal renal function for desired benefit. The later two would be able to retain intracellular and blood Mg.
Coconut oil is antifungal and three heaping tablespoons though the day seems more effective than anything else in preventing diarrhea from excess (therapeutic) doses of magnesium. Yet, we are told that magnesium, not the yeast + magnesium, is the cause of diarrhea.
If someone has low stomach acid, this can cause difficulty in breaking down various nutrients to an absorbable form. Chloride deficiency can cause low stomach acid. If someone had low stomach acid and they were taking magnesium oxide they could have difficulty in converting it to magnesium chloride for absorption.
Retention of magnesium may take up to a decade to correct.
It is theorized that CFS/Fibro et al. syndromes represent finitely variable combinations of multiple systemic dysfunctions which all share a common underlying etiology at the subcellular level: magnesium deficiency plus concomitant fluoride excess (MDFE).
Cautions:
Individuals may have an impaired ability to have a normal reabsorption in the renal nephron. They just excrete it. This suggests some kidney damage.
If cases of insulin resistance, it would also be difficult for the insulin-requiring cells to take up Mg. Insulin is necessary for Mg uptake in those tissues that require insulin.
Magnesium supplementation is known to interact with many different pharmaceutical drugs and it is wise to know what these are when treating patients. Certain drugs will increase the loss of magnesium in urine. Thus, taking these medications for long periods of time may contribute to magnesium depletion.
Magnesium may make tetracyclines (Doxy,Mino, etc) less effective. Take magnesium supplements 1-3 hours before or after ingesting tetracycline. Mg with Glipizide or Glyburide may further lower blood sugar leading to blurred vision, tremor (shaking), hunger, sweating, headache, skipped heartbeats, confusion, nervousness and extreme tiredness. Neurontin (Gabapentin) binds Mg in the GI tract and results in a malabsorption of both oral Mg and Neurontin (PDR says 24 percent).
Magnesium supplementation in with Lithium therapy, dehydration, Addison’s disease, Hypothyroidism or renal failure is contraindicated. Though extremely rare, severe magnesium intoxication is manifested by a sharp drop in blood pressure and respiratory paralysis. Disappearance of the patellar reflex is a useful clinical sign to detect the onset of magnesium intoxication. In the event of overdosage, artificial ventilation must be provided until a calcium salt can be injected intravenously to antagonize the effects of magnesium.
Resources:
DEPTH:
http://www.mgwater.com/index.shtml PUBMED: Magnesium Metabolism and its Disorders
/www.ncbi.nlm.nih.gov/pmc/articles/PMC1855626/ FREE BOOKS ONLINE:
MAGNESIUM DEFICIENCY IN THE PATHOGENESIS OF DISEASE Early Roots of Cardiovascular, Skeletal and Renal Abnormalities by Mildred S. Seelig, M.D., M.P.H., F.A.C.N.
www.mgwater.com/Seelig/Magnesium-Deficiency-in-the-Pathogenesis-of-Disease/preface.shtml MAGNESIUM: THE NUTRIENT THAT COULD CHANGE YOUR LIFE by J. I. Rodale with Harald J. Taub
www.mgwater.com/rodtitle.shtml These excerpts do not reflect my personal opinion as some were copied in the first person. My opinion is noted as 'Personal Note'.
Forms are not covered here. Mg Threonate warrants further investigation as it improves brain function: https://www.nootropedia.com/magnesium-threonate/
Consult your physician prior to supplementation.