A1298C

What were your results? I just got mine back and they were heterozygous. My LLMD said she isn't very worried about it but she thinks I could have a slight methylation issue.

DaveNJ41 said...
Mine was also heterozygous

So thats only one gene copy for it, not both. Prob not a big deal then.

A1298C and M677T are the two most common MTHFR genetic mutations that contribute to methylation. Most MDs will only test for these two but there are hundreds. And the combinations of mutations also create issues.

So, testing and treating for only one is a bit misguided although I know some people do well on methylation support. I think it's good to assume that if you're struggling with Lyme & Co you probably have some methylation and detoxing blocks. The testing is not too important. If you're interested in what mutations you might have, it's more productive to have your DNA data analyzed in order to gut a much fuller picture (through 23andme type organizations and other services that interpret the data for you - lots of info about this on the forum and online).

Most people - even healthy people - are heterozygous (one copy) for one of the MTHFR mutations, which is appx 30% reduction in function. Homozygous (two copies) generally results in 60% reduction. There is supplementation you can explore but again, it's hit-or-miss.

-p

DaveNJ41 said...
Thanks p! I want to explore more into this and would love to hear from others in terms of what they’ve done to support their methylation issues and what has worked best/what hasn’t worked?

Dave there was a recent post on MTHFR a couple weeks ago. We had a lot more gene posts a few years ago when 23andme raised in popularity. As P stated there is a lot more to the picture, but those you are referring to get all the attention.

My 23andme raw data interpretation reported on 300-400 genes, 38 or so pages worth. That was $50 (Sterling app from MTHFR support) on top of 23/me raw data ($100, now $200).

To see the big picture with plenty of methalation charts with arrows, diagrams ect go to heartfixer.com
Its one huge biochemistry puzzle with "sub-loops" ect. I look at this all more in terms of mechanics; ex: bad auto mileage because tires had 10 psi vs a worn engine ect. Lots of overlaping issues in us just like cars.

I accidentally discovered a couple things from 23/and me that can be life-saving to know. Not kidding. 2 things that can kill me, which I know know what to look out for and it already helped an ER Dr since I knew what it was. Conventional testing of this particular non-lyme "gene issue" proved 23/me was right. That Dr thought is was pretty cool that I already new of this possibility happening. Now I'm well informed, if it happens again - I know ahead of time what they (ER) need to do.

Some people dont want to know their gene health issues and would rather just not know, and possibly get sick and or die early. I like to know and prevent if possible.

Also, do regular drs. believe in this? If something should show up on the test who will treat the problems?

aphysicalwreck said...
Also, do regular drs. believe in this? If something should show up on the test who will treat the problems?

Well I made a believer out of my "regular" Dr.. Read my previous comment if you haven't. My issue (was not a methaltion thing) developed and I pretty much told ER what might be going on and I was correct. Conventional medicine testing also confirmed it via several individuual gene tests and I received meds, self daily shots for a week, till the issue normalized.

If I blew it off (like most men do) I could of had a stoke that night, or died - I avoided both but know what the signs feel like now. If it happens again, I can slow it down but will still need medical care.

As far as treating it would all depend on what you find. "normal issues" per conventional medicine can be found on 23andme in addition to the "odd" gene issues like MTHFR) if you get what I'm saying. The free interpretations dont tell much. You get what you pay for.

"Regular " Drs generally arent going to do anything for the methalation genes.

Obviously from my experience based on real life facts, I highly recommend this.

Post Edited (astroman) : 11/8/2017 12:48:53 PM (GMT-7)

I just dont see how my LLMD can blow my results off when I show very very high B6 levels and i AM NOT taking ANY B supplements.

That and the fact that my MTHFR A1298C being heterozyguys to me means TREAT!

I just dont know where to start.. Can someone tell me what supplements I should take and where to start/how high to go?

DaveNJ41 said...
Hi all,
Thank you all so much for your responses, it's something to think about!

Astroman- I paid for the 63 page report on Sterlings website, it shows A LOT of methylation issues, COMT, MTRR, MTHFR, HLA-DR, etc., etc.

CAN'TI JUST HAVE NEW F'CKIN GENETICS/NEW BODY?!?! LOL.

Like others have said, is this something to be actually treated or is this setting us up for more stress and worrying that every single thing that our bodies do, genetics, cellular processes is something we need to act on/treat/worry about? I do need to review this report with my doctor and a naturopath, professionals who actually understand these genetics and mutations, what to do about them, what supplements to take, etc.

I know we're all very well researched and well-versed in certain areas but we do need to remember that none of us are clinicians/professionals (not trying to be rude I promise) so it would be wise for us to follow up with our providers.

I'm not sure if I'm making this up in my head because I want to get better so badly or this is an actual issue but I do think I detox/methylate pretty poorly. I'm happy to send my report to anyone who's curious to see it.

Oh, you did get the good report,.so I was peachen to the chior...LOL We cant treat all of these. Some they dont even have info on. The red ones (two copies) matter most, and then is still might not. The Drs I reviewed it with new which ones were important. The liver pages are obviously important- and even for lymies, if they dont detox well. Not worth stressing over.