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Please read - Gram negative (Bart) / biofilm / parasites -> melatonin Killer?

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Posted 5/26/2019 9:11 PM (GMT 0)
Just discovered this. Thoughts?

https://www.ncbi.nlm.nih.gov/m/pubmed/18289175/

https://www.ncbi.nlm.nih.gov/m/pubmed/29390164/

https://www.sciencedirect.com/science/article/abs/pii/S0753332217348011?via%3Dihub

Post Edited (isitlyme) : 5/26/2019 3:21:48 PM (GMT-6)

Posted 5/26/2019 10:16 PM (GMT 0)
the problem is that you can likely never take enough melatonin to kill bart or anything else without sleeping all day.
Posted 5/26/2019 10:31 PM (GMT 0)

Lapis_29 said...
the problem is that you can likely never take enough melatonin to kill bart or anything else without sleeping all day.

I dont thing these are high doses:

" but results showed that melatonin had antibacterial effects against these microorganisms after 48 hr of incubation in lower doses [concentrations between 31.25 to 125 microg/mL (0.13-0.53 mM)]."
Posted 5/26/2019 10:48 PM (GMT 0)

isitlyme said...

Lapis_29 said...
the problem is that you can likely never take enough melatonin to kill bart or anything else without sleeping all day.

I dont thing these are high doses:

" but results showed that melatonin had antibacterial effects against these microorganisms after 48 hr of incubation in lower doses [concentrations between 31.25 to 125 microg/mL (0.13-0.53 mM)]."

----------------------------------

oaky but what actual Mg dose do you need to take to get those plasma concentrations?
Posted 5/26/2019 10:54 PM (GMT 0)
Considering that the average person has about 5 liters of blood, to get 31.25 microg/mL, you'd need 160 mg of melatonin.
Posted 5/26/2019 11:02 PM (GMT 0)
Oops, yes thats right too much. Lapis and Quin you are right.

31 ug = 0.031 mg melatonin

5 liter = 5000 mililiter

0.031 x 5000 = 155mg

But well better some melatonin than none.

And why do they say lower doses!?????? Something must be wrong here
Posted 5/26/2019 11:04 PM (GMT 0)
I rounded up, but yeah... 150-160 mg of melatonin seems like too much.
Posted 5/27/2019 2:10 AM (GMT 0)

Quin said...
I rounded up, but yeah... 150-160 mg of melatonin seems like too much.

“Seems”???
Lol
Posted 5/27/2019 2:51 AM (GMT 0)
LOL well 150mg would be a typical starting dose for many antibiotics. I don't think it would be a good idea to take that much melatonin.
Posted 5/27/2019 3:39 AM (GMT 0)

Quin said...
LOL well 150mg would be a typical starting dose for many antibiotics. I don't think it would be a good idea to take that much melatonin.

Nope it wouldn’t.

The usual dose is less than 5 mg
Posted 5/31/2019 7:27 AM (GMT 0)

Somebody said...
the problem is that you can likely never take enough melatonin to kill bart or anything else without sleeping all day.


I think most would be happy to sleep for a few days to kill bart. 150mg is safe, Melatonin doses up to 6 gram/day levels were tested for extended periods (month) in Sweden.

https://www.medscape.com/viewarticle/472385_8


The acute toxicity of melatonin as seen in both animal and human studies is extremely low. Melatonin may cause minor adverse effects, such as headache, insomnia, rash, upset stomach, and nightmares. In animals, an LD50 (lethal dose for 50% of the subjects) could not be established. Even 800 mg/kg bodyweight (high dose) was not lethal.[138] Studies of human subjects given varying doses of melatonin (1-6.6 g/day) for 30-45 days, and followed with an elaborate battery of biochemical tests to detect potential toxicity, have concluded that, aside from drowsiness, all findings were normal at the end of the test period.[139,140][url]

Post Edited (Luvstruck) : 5/31/2019 1:33:49 AM (GMT-6)

Posted 5/31/2019 9:20 AM (GMT 0)
I concur fully with Luvstruck`s comments. I know first hand people engaged in a clinical trial that were given a few grams (I think it was 6 gr) of melatonin daily for a few weeks and it was safe and they did not elicit a particular somnolence. Yes a bit sleepy but not sleeping for hours at all. The clinical trial, though, had nothing to do with antibiotic effects of melatonin.

My few cents.

Pillin.
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