HealingWell
Search Close Search
☰

Drinking large amounts of hyaluronic acid has really helped my joint pain

Support Forums
>
Lyme Disease
✚ New Topic ✚ Reply
❬ ❬ Previous Thread |Next Thread ❭ ❭
Posted 3/11/2019 9:59 PM (GMT 0)
Drinking large amounts of hyaluronic acid has really helped my joint pain.

The only way to do this is to buy the pure HA bulk powder and mix it with some water. Trying to take large amounts using supplement capsules will break the bank.

Basically I just put about 200 mgs in some water, wait for about 1 hr for it to gel up then drink it down. YOu can also mix it up and let it sit all night if you want to. Really seems to help ease my joint pain noticeably. Am also taking collagen 5 gr/day, glucosamine hcl 3 gr/day, but neither of those has had the noticeable lessening of pain like HA has.

This study showed that lyme depletes HA production by the cells quite a bit: 40% - 60% less HA when the lyme bug is present. Also notes the inflammatory cytokine IL-6 production is higher with lyme.



Somebody said...


Borrelia burgdorferi decreases hyaluronan synthesis but increases IL-6 production by fibroblasts

https://doi.org/10.1006/mpat.1994.1027

Abstract

Despite the prevalence of clinical data on human Lyme disease, little is known about the immunopathologic effects of the causative organism on the host. We studied the effect of Borrelia burgdorferi on hyaluronan (hyaluronic acid, HYA) production and the effect on interleukin-6 (IL-6) synthesis by cultured fibroblasts. The cell line employed in this study produced an average of 1406 ng of hyaluronan/ml within 48 h. Using both a morphological staining protocol and a quantitative radiometric assay, we noted that in the presence of a low dose of Borrelia (9.4 × 105 cells/ml) the hyaluronan production decreased to an average of 1008 ng/ml, a significant difference (p < 0.05) from the amount of hyaluronan produced by the cells alone.

The reduction was even more significant (p < 0.01) when a higher dose of Borrelia (9.4 × 106 cells/ml) was used giving an average hyaluronan concentration of 682 ng/ml. In contrast, we found that Borrelia stimulated the cells to produce IL-6 from a baseline of 293 pg/ml to a maximal value of 842 pg/ml (p < 0.01). The spirochetes had no significant effect on cell viability, nor were we able to demonstrate invasion of the cells by the bacteria. Both a decrease in hyaluronan and an increase in IL-6 may correlate with the pathogenicity of Lyme disease in man.

Post Edited (Lapis_29) : 6/12/2019 9:09:42 AM (GMT-6)

Posted 3/12/2019 5:02 AM (GMT 0)
So un-capsulized hyaluronic acid (HL) does not create any burning throat feeling "on the way down"? I see its used topically on skin, so it must not be very strong.

I assumed the main reason for the capsule form of Betaine hydrochloride (HCL) was it avoided "burning" on the way down, as this as strong stuff.
Posted 3/12/2019 2:10 PM (GMT 0)
No, goes down smooth as silk, you can even rub a little on your face every time you drink it to give it a nice glow

This is what I bought right here. That bag will last for a long time.

https://www.amazon.com/hyaluronic-anti-aging-supporting-non-irradiated-non-contaminated/dp/b01dpw5c5w/ref=sr_1_4?crid=6v7hojh2n1p4&keywords=hyaluronic+acid+powder&qid=1552400017&s=gateway&sprefix=hyaluronic+acid+po%2caps%2c177&sr=8-4
Posted 6/12/2019 5:34 PM (GMT 0)

Lapis_29 said...
No, goes down smooth as silk, you can even rub a little on your face every time you drink it to give it a nice glow

This is what I bought right here. That bag will last for a long time.

https://www.amazon.com/hyaluronic-anti-aging-supporting-non-irradiated-non-contaminated/dp/b01dpw5c5w/ref=sr_1_4?crid=6v7hojh2n1p4&keywords=hyaluronic+acid+powder&qid=1552400017&s=gateway&sprefix=hyaluronic+acid+po%2caps%2c177&sr=8-4

Above link says non gmo, great.

Below link, same brand, says from corn, bummer for some people. Corn creats cytokin release tested my blood. Might see if there are other sourced types/brands.

https://www.amazon.com/ask/questions/tx3kctwi8wqnj8p/?
Posted 6/13/2019 12:42 AM (GMT 0)
I had been taking the capsules without noticing any benefits. Maybe I'll try this method.
However, I do remember reading about HA increasing rates of some types of cancer. Perhaps it's not a significant increase or it's just worth the risk?
Edit: just reread where you said you were taking 200mg a day. I don't think that's a crazy amount...

Post Edited (potsnpans) : 6/12/2019 6:47:06 PM (GMT-6)

Posted 7/27/2019 9:25 PM (GMT 0)
Lapis / Astro would using this topically with DMSO increase absorption? I have a few trouble spots that I would like to start trying new things on. Never tried high dose HA orally either. I have bought BioPure HA and taken that as Dr Klinghardt claims it lures the lyme bugs out of the joints into the blood stream to eat the HA you ingested, but I've probably only taken 6mg doses per day.

PS that site to bulk HA says to use distilled water. Is that necessary?
Posted 7/27/2019 10:11 PM (GMT 0)
Funny....I was looking for this past post the other day and made a new one asking Lapis about it.

When driving in anything topically I just examine all the ingredients and think if this (what ever it is) would be harmful in the blood or not. DMSO topically certainly drives in itself and whatever else into the target area. It makes Penetrex way more effective, just did this after a post workout shower.

Interesting to see if Lapis tried HA this way.
Posted 7/28/2019 5:49 AM (GMT 0)
Astro - I am considering trying penetrex and dmso as well. I would probably just try one thing at a time, but debating between HA and penetrex currently. Connective tissue in my palms and heels flared up causing a little popping and pain. I think it was due to a severe herx mixed with autoimmunity to dapsone, the sulfa drug I was taking.
Posted 7/28/2019 2:03 PM (GMT 0)
no need to use distilled water, tap or spring is fine.

Thsi study showed HA is very orally bioavailable in dogs and rats and I imagine its the same for humans. After an oral dose of HA is was found to be concentrated in joints, vertebrae and salivary glands four hours after administration. So I just stick with oral and feel like it works well.

https://pubs.acs.org/doi/pdf/10.1021/jf8017029

I have tried to rub some dmso on top of topically applied HA and found it didn't mix well. You could try to mix the 2 together first and then apply. If you do please report and let us know how it went.
Posted 7/28/2019 6:21 PM (GMT 0)
Thanks lapis! I plan on trying this soon.

Right now I'm kinda in the middle of some other changes and I'd like to wait until things level off until I add the HA. Do you remember how long it it took for you to notice effects?
Posted 8/3/2019 1:36 PM (GMT 0)
Any opinions on the importance of "high molecular weight" hyaluronic acid? Trying to find a good product online and reviewers seem critical of every product I can find regarding this.

Lapis- would you mind sharing your source?
Edit: I just reread the beginning of the thread to see the link to microingredients brand from Amazon.

Post Edited (potsnpans) : 8/3/2019 7:54:36 PM (GMT-6)

Posted 8/3/2019 11:15 PM (GMT 0)
I ordered this yesterday. Arriving tomorrow. Super excited to try it. I just got the kind Lapis recommended.

I have also been using Penetrex and DMSO that Astro recommends. First putting the Penetrex on then painting DMSO over it in a thin layer with a 1" wide horsehair brush. So far I notice a relief in pain for sure. No relief in what I call ropey tissues. These weird 1/8" to 1/4" inflamed tissue on top of the tendons that developed and cause pain and cracking. Most developed after sulfa antibiotic use. Which may have been due to a herx of lyme or a herx of bart coupled with an autoimmune reaction. I am allergic to bactrim, but seem to do alright with dapsone.
Posted 8/5/2019 1:49 AM (GMT 0)

potsnpans said...
Any opinions on the importance of "high molecular weight" hyaluronic acid? Trying to find a good product online and reviewers seem critical of every product I can find regarding this.

Lapis- would you mind sharing your source?
Edit: I just reread the beginning of the thread to see the link to microingredients brand from Amazon.

no dont get high molec weight, that is inflammatory inducing.

This is what I use

https://www.amazon.com/gp/product/b01dpw5c5w/ref=ppx_yo_dt_b_search_asin_title?ie=utf8&psc=1
Posted 8/5/2019 4:25 AM (GMT 0)

Sheekster said...
I ordered this yesterday. Arriving tomorrow. Super excited to try it. I just got the kind Lapis recommended.

I have also been using Penetrex and DMSO that Astro recommends. First putting the Penetrex on then painting DMSO over it in a thin layer with a 1" wide horsehair brush. So far I notice a relief in pain for sure. No relief in what I call ropey tissues. These weird 1/8" to 1/4" inflamed tissue on top of the tendons that developed and cause pain and cracking. Most developed after sulfa antibiotic use. Which may have been due to a herx of lyme or a herx of bart coupled with an autoimmune reaction. I am allergic to bactrim, but seem to do alright with dapsone.

I did a lot of cross friction massage over various tendons. Fixed some, and some are still "projects" needing more time. Tools used: Thereacane, golfball, LaCross ball, radius edged countertop and even the smooth handle part of a butter knife- followed by DMSO
Posted 8/6/2019 2:31 AM (GMT 0)
Astro - Do you feel that DMSO on it's own is healing to the connective tissue? Can I leave DMSO out in an open container like a glass bowl and use it for a few days without it going bad? That is usually what I do. Dump a tiny amount into a glass bowl and use it until it is out. You need such a small amount on the joints it is hard to pour out that little of an amount. I notice if I use too much it will dry up my skin and cause it to flake.

On another note, I got my hyaluronic acid and I have been mixing it in water and letting it sit for an hour before drinking. Man it is like boogers going down haha.
Posted 8/6/2019 7:00 AM (GMT 0)
Sheekster - My husband has some DMSO in a small glass bowl with Saran wrap covering it.

He’s still here... lol.

He has used dmso for several issues for the past 15 years.
He has a couple paint brushes that he only uses for painting the DMSO on his skin.

He considers DMSO the miracle solution.

He bashed his leg at work just below the knee cap. The tendon was swollen and he could hardly walk. After about 6 months he went to the specialist and his solution was to operate and slice part of his tendon off - to relieve the pressure around the knee area.

My husband didn’t like the sound of that - he got out his DMSO and painted it on daily - I can’t remember how many days - but the swelling went down and has not had an issue with it since.

Another instance - he was in a bad car accident - was Tboned at an intersection - a lady ran the red light. Totaled his car .
A year later he still had issues with his upper back in the right scapula area.
The Drs said he was stuck with the pain - and in fact they said it wouid get worse as arthritis would set in eventually.

He got out the DMSO and applied it daily until the pain subsided.

That was several years ago .

So - my point is he doesn’t use DMSO to facilitate the delivery of other topical meds...for him it’s a stand alone treatment.

It might help with your connective tissue.
Posted 8/6/2019 8:03 AM (GMT 0)
Wow Girlie. Thank you. I didn't know it was so powerful on it's own. Glad to hear about that.

Regarding leaving the DMSO in a bowl and using it for multiple days... I was more wondering if it is still effective. It seems like it is, but I am not sure. I didn't really think about a safety risk until you mentioned it...
Posted 8/6/2019 2:29 PM (GMT 0)

Sheekster said...
Astro - Do you feel that DMSO on it's own is healing to the connective tissue? Can I leave DMSO out in an open container like a glass bowl and use it for a few days without it going bad? That is usually what I do. Dump a tiny amount into a glass bowl and use it until it is out. You need such a small amount on the joints it is hard to pour out that little of an amount. I notice if I use too much it will dry up my skin and cause it to flake.

On another note, I got my hyaluronic acid and I have been mixing it in water and letting it sit for an hour before drinking. Man it is like boogers going down haha.

Well....what girlie said..

In my case the little amount I dont use in an application, I just leave in the shot glass I use for dispensing- in the bathroom counter top corner. No kids in my house, no climbing pets either.

It works on it own, I wouldn't say its a miracle, but it does work better for my long time injuries if applied over other natural topicles.

I have plenty of 2 wheel competitive crashes in the past (throttle and pedal) that did not heal correctly in my decades of past lyme. My own tissue work and these topical applications are healing what no professional health care providers could correct, pt, chiro, dr whoever.. I realize some may be permanent, but im not quitting yet.
Posted 8/6/2019 4:44 PM (GMT 0)

Sheekster said...
Wow Girlie. Thank you. I didn't know it was so powerful on it's own. Glad to hear about that.

Regarding leaving the DMSO in a bowl and using it for multiple days... I was more wondering if it is still effective. It seems like it is, but I am not sure. I didn't really think about a safety risk until you mentioned it...

What you don't want is dirt in it. So that's why it needs to be covered.
Posted 8/6/2019 9:32 PM (GMT 0)
Girlie - True. Dust or dirt. Good point. I'll try and cover it from now on.

Astro - Thanks. I too have had a lot of 2 wheel pedal crashes. smile Most everything healed up without a hitch though. Until the cards came crashing down in 2016 with lyme growing out of control. Before then everything was fine and dandy.
Posted 8/7/2019 4:07 PM (GMT 0)

Lapis_29 said...
no need to use distilled water, tap or spring is fine.

Thsi study showed HA is very orally bioavailable in dogs and rats and I imagine its the same for humans. After an oral dose of HA is was found to be concentrated in joints, vertebrae and salivary glands four hours after administration. So I just stick with oral and feel like it works well.

https://pubs.acs.org/doi/pdf/10.1021/jf8017029

I have tried to rub some dmso on top of topically applied HA and found it didn't mix well. You could try to mix the 2 together first and then apply. If you do please report and let us know how it went.

Do you absolutely need to use water? No juice, just water? I find it hard to get down with water. I’m grateful for your post on this became knees are absolutely shot and I want to get them healed, otherwise I’m headed for a walker at the very least.

Thank you
Posted 8/7/2019 4:56 PM (GMT 0)
Juice would be just fine. Also take some Collagen II (most collagen supps are I and III, but you need II for joints) Jarrow is a good source for that. And glucosamine also.
Posted 8/7/2019 5:38 PM (GMT 0)

Lapis_29 said...
Juice would be just fine. Also take some Collagen II (most collagen supps are I and III, but you need II for joints) Jarrow is a good source for that. And glucosamine also.

Thank you 🙂
Posted 8/7/2019 6:22 PM (GMT 0)
I tried the shotgun approch to collagen this time:

This > "Ancient Nutrition Dr. Axe Multi Collagen Protein, Powder" has all five types of collagen. I can tell a difference in stiffness or lack off, after the gym.

Reg protien : milk, whey, veggie,........... none did anything that I could tell.
✚ New Topic ✚ Reply