Disulfiram - Part 3

jolaleye121 said...

steelogreens said...
Hey all,

Yesterday was the day from hell. Literally just lying in bed like a potato. Likely overdid it because it took so long to hit (yes dumb me). Not taking any today because I have enough in my system.

I feel exhausted. Body feels like I did a full body workout at the gym and every muscle in my body is aching.

There is this pressure that’s being lifted.

This is the first thing I’ve taken where I feel there is light.

That's good to hear, are you suffering from neurolyme? If my appointment with communicable disease doesn't yield anything I am going to give it a go because I'm up a smelly creek without a paddle

@Jovalyme

When I took the herbs, I took Japanese Knotweed, Salvia Milthorizia, and Uncaria Rhynchophyla. I would have added scutellaria baicelenssis but I couldn't afford to. That's the basic protocol for Neurolyme in Buhners book. 3 teaspoons of Jap Knotweed, 3 spoons half and half salvia and scutellaria and 3 spoons of Uncaria rhynchopyla a day. It helped a bit but I'm too poor to keep it up. So I've fought for the doxy I got today.

My biggest symptom in terms of life altering is brain fog, head pressure, light and sound sensitivity, along with memory issues and insomnia.

Depression that comes with Lyme obviously.

This is a completely different animal disulfarim. It’s as though I’m herxing and going through hell, but yet I see how it can take me back to normalcy. Think of a really hard math teacher but you know in the long run it will be good for you.

Bizarre metaphor I know lol.

If you do take it stick to the dose. Nothing was happening for two weeks and I just upped it with doctors consent but not thinking it was going to be so intense but trust me it is.

We are at a very important point for lyme patients, especially the ones who've been struggling with these illnesses a long time. Disulfiram, azlocillin, methylene blue, gallium nitrate... there are a lot of new approaches that are looking incredibly promising. Patients with late stage disseminated lyme disease are not dead in the water, in fact, we have never been better positioned for recovery.

That said, incredibly potent agents like DSF that have strong CNS penetration have to be used carefully (slow low frameworks) in the patients who have strong neuro involvement (imo). Overly aggressive approaches may trigger MCAS/immune system storms (my hypothesis)... that said, this agent is pretty incredible as two-fer (borrelia, babesia activity, amongst other things). It also seems like it might be less prone to resistance due to some type of rock solid mode of action(s) that may involve some type of disruption of metalloprotein ion uptake of the pathogens (there are also other potential explanations as regards metal chelation and pathogen destruction with this drug, but this potential mode of action would seem to be impossible for the pathogens to evolve resistance to as the metal pathways are necessary for their function). So what is potentially great about this is it means we can do low dose and pulse (treat to tolerance) with less fear of causing resistance. This is all speculation of course, we'll get more info with more research and also as we build up anecdotal evidence (which should not be discounted). This is a very exciting agent, but it is like fire imo, powerful powerful powerful, must be used with care!

Could even dose more conservatively, like 50-60mg 1x per week, to really hedge and be careful. There are patients doing this.

As regards autoimmune, I believe all autoimmune symptoms are a downstream effect of a causative mechanism (so for most of us this is infections and or other type of toxins). If one has continuing "autoimmune" issues it is because there is still pathogen or other toxin causing these symptoms. I do not believe they occur on their own (out of the blue) or are self-sustaining, there needs to be a driving force. Modern medicine has yet to adopt or align with this thinking. I do think they eventually will. We do not see autoimmune issues in nature, disintegration occurs because of stress factors and disease. Unfortunately most people (including many researchers and doctors) are falling short in the causality chain and mistaking downstream symptoms as self-contained issue. But basic use of Occam's Razor the simplest explanation is that infections and or other toxins are driving the symptoms, imo.

HI Jova,

Yeah I was one of the first documented cases of B. duncani. I was treating many years ago but my insurance stopped paying, I ran out of money, etc... You know the story as so many of us have been there.

I heard about the possibility of DSM not hitting duncani from a post written by some guy named Charles on lymenet as well as Dr. L's third case study. There were 3 people in his "study" of sorts who were treated with DSM. One had a clinical diagnoses of Babesia and he's doing well, the other had lab confirmed B. microti and he's also doing well, and the third one has lab confirmed B. duncani and he's being (or already has been) retreated. Don't know how he's doing. So that's 2 cases which isn't much to go on, but still. B. duncani is known for being harder to treat than microti so it wouldn't surprise me if DSM doesn't hit is as well.

Even so, I'll still be very thankful if I can at least get rid of Lyme. I would think my body would be better able to handle the duncani without Lyme on board. My main concern is that the duncani may prevent the Lyme from being killed as it's known to do that and the third person in the study continued to test positive for Lyme and duncani even after a full course of DSM.

Jovalyme : "It does look like disulfiram is a breakthrough drug and I'm surprised more people here aren't trying it to be honest. Everything I've read and some of the youtube videos I've seen show that it clearly does something quite powerful."

I've been on this forum since 2014. ....and Disulfiram isn't the first 'breakthrough' treatment I've seen.

It's still early in the game to know what the outcome will be.....I truly hope it proves to work.....and I will be jumping on the bandwagon...with everyone else...

Part 4 https://www.healingwell.com/community/default.aspx?f=30&m=4156966