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Questions about Malarone

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Posted 10/17/2019 12:13 PM (GMT 0)
I'm currently on Malarone for babesia and I have some questions about it, I tried searching for answers to these questions but couldn't find any.

1. I know you have to take it with meals with fat for better absorption, but how much of a gap should it be between taking the Malarone and eating the fatty meal? Like, can I take the Malarone and then prepare a meal which takes about 9-10 minutes or so, so I start eating around 10 minutes after I take Malarone. Is this fine, or do I need something to eat instantly after taking it?

2. If I miss eating a fatty meal with the Malarone for a day or two will that be detrimental to the treatment?

Sorry if these are silly questions but I'd really like to know, thanks.
Posted 10/17/2019 12:49 PM (GMT 0)
I was just prescribed Malarone last night to replace my Alinia.

1. I haven't used mepron in many years, bu back then I would simply take a spoonful of peanut butter just before taking either mepron/malarone to improve absorption.

2. Missing a fatty meal for a day or two while on malarone will reduce its effectiveness, and waste money. I don't know the price difference between Mepron and Malarone but recall that Mepron was very pricey so don't waste a dose by not taking fats with your meds.

no questions are silly in this forum...
Posted 10/17/2019 1:49 PM (GMT 0)

tickbite666 said...

2. Missing a fatty meal for a day or two while on malarone will reduce its effectiveness, and waste money. I don't know the price difference between Mepron and Malarone but recall that Mepron was very pricey so don't waste a dose by not taking fats with your meds.

Reduce it's effectiveness? As in it stops working? I'm honestly not worried about the money, I got that covered. i'm more worried about it no longer working if I forget to eat fat once.

What I've been doing is eating 100g of peanut butter or walnuts right after taking the Malarone and it's been working out for me pretty well. I just wanted to try something new and make a new meal and I was wondering if 10 minutes apart from me taking Malarone and eating the meal would be fine.
Posted 10/17/2019 1:59 PM (GMT 0)
https://www.rxlist.com/mepron-drug.htm

"Administering atovaquone with food enhances its absorption by approximately 2-fold. In one trial, 16 healthy volunteers received a single dose of 750 mg MEPRON suspension after an overnight fast and following a standard breakfast (23 g fat: 610 kCal). The mean (±SD) area under the concentration-time curve (AUC) values under fasting and fed conditions were 324 ± 115 and 801 ± 320 h•mcg/mL, respectively, representing a 2.6 ± 1.0-fold increase. The effect of food (23 g fat: 400 kCal) on plasma atovaquone concentrations was also evaluated in a multiple-dose, randomized, crossover trial in 19 HIV-1-infected volunteers (CD4 <200 cells/mm³) receiving daily doses of 500 mg MEPRON suspension. AUC values under fasting and fed conditions were 169 ± 77 and 280 ± 114 h•mcg/mL, respectively."

10 minutes is just fine, but I would eat first. In one study the subjects waited for 1 hour to take Mepron.
Posted 10/17/2019 2:06 PM (GMT 0)

1029384756 said...
10 minutes is just fine, but I would eat first. In one study the subjects waited for 1 hour to take Mepron.

I see, I didn't think eating before or after would make much of a difference. As long I take the Malarone at the same time with a spoonful of peanut butter afterwards. I've been doing this for 5 months and I feel this method has worked really well for me.
Posted 10/17/2019 2:15 PM (GMT 0)
With drugs that work better with food, I don't like to take them on an empty stomach, even if it's only for a short time. It might not make too much of a difference but I always want to make sure I'm getting the most out of a drug. That's just my opinion on the matter.
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