Disulfiram - Part 8

yay it's day 2 of disulfiram.

Alright technically I haven't slept yet but it's past midnight so whatever.

Just took 125mg, lets see how this goes.

Yesterday I napped really deep, deeper than I sleep at night.

Feeling more energized than usual. I like it.

Hung out with my roommate till 1am, and still had energy left.

Part of me thinks this energy won't last, from what I've been reading from others.

Feels like increased dopamine. I'm also on adderall so this feeling feels familiar.

Thank you friend

Thank you Quin, that's really good to know, I'll definitely slow down.

Also, do you have any tracking updates on your package UnsightlyCignet?

I have had no reaction to alcohol taking 50 mg/day disulfiram. I had chinese food and sushi (with soy sauce), and had no reaction. I've been to the phlebotomist for blood tests and they did the usual alcohol swab thing, and I had no reaction to that.

Surprisingly, I got really high blood pressure from flagyl, but not from disulfiram. Disulfiram makes me pee, a lot.

Disulfiram does not have to be potent. You can take 30mg once a week and work your dose up. Folks jump into this way way way to fast and crash. It takes a long time to put humpty back together again.

I feel normal. Almost as if I have eliminated Burdorferi. I increased the dosage and had a little herx, but maybe it was just the side effect of the drug.

I think taking the smallest amount 30mg a week IS acceptable. I think starting off at anything above 62.5mg is counter productive, except perhaps a single booster dosage -- and only if you are restarting and know your baseline.

Taking 125, 250, 500 anytime before 6-8 weeks will set you back big time, perhaps even 2-4 months. You'll reach your goal faster if you start off slower for a longer period of time.

going from memory and experience:
it takes 5 days of dosages to "load up" because of the half life, minimum 7 days
after that it takes 5-28 days to kill anything immediate available, minimum 2-3 weeks
then it takes 12-28 days to reach one life cycle die off, minimum 2 weeks
and it takes 2-6 weeks to get over the multiplier effect, minimum 3 weeks
THEN you can establish a baseline and increase from the initial 62.5mg to 125mg.

my transition from 125mg to 250mg was 3 weeks. Here I am at 250mg and no sign of a disease.
Still going.. if I don't get a herx at 250mg in 10 days I'll up it. If I do, I'll wait 3 weeks. The 125->250 is quicker. The 0-62.5mg and 62.5mg->120mg is the longest and more critical part where it appears to be more effective.

🔹RainyCloud said...
Did anyone on DSF have lyme related eye floaters prior to treatment?

Yes, but mostly related to bartonella. If you've got this problem, make sure you take something for bart.

The problem is that, unlike borrelia which becomes dormant when attacked with antibiotics, bartonella actively resists antibiotics. Taking antibiotics that are insufficient to kill bartonella just makes it more aggressive. This is a risk with disulfiram. I found that my bartonella became more active, I got itchy, and blood tests showed that my bilirubin and vitamin B6 (a product of bartonella metabolism) went up.

I haven't tried methylene blue, but others here have found it effective against bartonella. I am taking minocycline.

regarding my "hey I'm at 250mg and I'm feeling good and not herxing" post, never mind.

Just got a major hangover, which is my herx. wow. taking my alkaseltzer now

the mouse study is very reassuring.

Hi Jova

Thank you so much for your comment, I really appreciate it.

The first day I did 62.5 and the following 2 days, I did 125mg each day.

Today is day 4 and I just took 125mg again.

Thank you for the warning too, that's really good to know. I really appreciate it.

I will be watching carefully for neuropathy but luckily haven't noticed anything yet.

The thing about my legs is familiar to me.

When I took antibiotics, my upper legs started becoming sore.

Then when I switched antibiotics, my upper legs became sore again.

When I did Buhner, my upper legs became sore again.

When I did BVT, my upper legs became sore again.

And now, after 3 days of Disulfiram, my upper legs are sore again.

It sounds bad but it's a great help to me, it allows me to exactly pinpoint when I'm herxing.

My theory is that maybe there are a lot of spirochetes in my upper legs.

I'm a "former" athlete and the main muscle group in my sport was upper legs.

Maybe that's why they like to hang out there? Lots of tissue?

Regardless, it just got worse in between my previous post and now, so I'm starting to herx fast.

I noticed the hypomania when I first took disulfiram, and then the next day I felt like crap. Since then it's not quite as intense, but I still get this manic/depression cycle at intervals of a few hours to a day or so. I was taking 50 mg per day but I started to herx a lot so I took a break for a few days. After a few days off the disulfiram I don't feel the psych effects, but I still have muscle aches (herx).