Histamine

There are sometimes questions on histamines so I thought I would post on the process of histamine issues. There are many components to this so this is not the only path to problems, but a common one for us.

People with elevated histamine levels often have low copper levels. This is common because our serum copper levels increase when our body detects an infection. The copper helps our immune system kill pathogens but over time, our liver releases so much copper and it is lost through the inflammatory process. We don't replace it fast enough so we become low on copper. This is one of the reasons we can have increased headache frequency. We often see mineral depletion with low copper with MTRR mutations. One way copper gets elevated just before it gets depleted is when molybdenum is low. Eating more sulfur containing foods decreases molybdenum and chronic yeasts decrease molybdenum as well. We then get in a situation where we are low on molybdenum and copper. This is common with chronic inflammation. Without enough copper, we can't break down serotonin and dopamine correctly. Too much copper in our initial phase increases MAO activity and can cause over stimulation

Eating alkaline foods can help you limit copper loss. BHMT8, C677T, and MTHFR03 are all genes that give us a predisposition for H pylori and decreased copper levels.

Cherries contain quercetin and this decreases histamine. They are also a source for melatonin which we use as an antioxidant to reduce oxidative stress. Melatonin never gets a chance to regulate our day/night cycle because it is used for more important things like reducing free radicals and glutamate.

I wrote several paragraphs about histamine and never discussed histamine. This is because it is a byproduct of something else and it gets increased to help our body, not hurt it. Find what is causing the problem and correct it. That sounds a lot easier than it is as we often have multiple bacterial issues at the same time or find what chemical is directly causing histamine release and avoid that chemical. It may take some time, but it can be done.

My histamine intolerance really didn't flare up with certain foods foods until I treated my thyroid with np thyroid and then kelp(iodine), then my bartonella went full blown, remind you some Doctors like Hirsch speculate bartonella likes to hide in the thyroid due the abundance of blood circulation.
https://youtu.be/tgjjtdapfdi?t=912

The histamine intolerance followed with a whole list of other psych and PANS symptoms I listed after bartonella flared. Luckily disulfiram did a whole lot of magic for my PANs symptoms, as it's doing a lot for some of Dr. K's patients as well. And guess what Georgia Hunter, I didn't have to go on a vegetarian diet, I eat plenty of meat. I'm also slowly starting to release carbs back into my diet, sometimes the herxing flares while being on Disulfiram, but I'm getting better every week being on the drug.

https://www.lymedisease.org/kinderlehrer-crazy-sick/
"He is sensitive to gluten, dairy, and yeast, which I suspected from the pattern of his food cravings. He had a positive Cunningham Panel consistent with PANS. After major improvement on antimicrobials and intestinal support, he suffered a relapse triggered by a mold exposure. Now on disulfiram, he is doing much better."

I'm also starting to see more patients, like a recent man in his 20s report on the disulfiram facebook group getting most of his PANS symptoms reversed after being on disulfiram for 3 months. Incredible, but I know he said those 3 months were herxing hell. I was on disulfiram for the last 2 1/2 months, in the the last three weeks I was treating with rifampi and disulfiram, similar to what Dr. K is doing, wasn't fun I'll tell you that much. I wonder if there's ever been this of an effective drug for chronic lyme patients, it's too bad others have their mind up thinking that disulfiram doesn't seem to kill bartonella and just flares their symptoms. Seems to be not the case with Dr. K's patient, or Liengners were also on a boat load of psych drugs, then after taking disulfiram they no longer need them.

My suspicion that SIBO may play a role, but Bartonella is a big reason for gluten intolerance, dairy inotelerance and a whole list of PANS psych symptoms. One vicious bug, by no surprise to me the project paperclip scientist chose it for the ticks. lol https://youtu.be/qjfn5y5iw_8?t=569

Anyways, cheers, we're making progress!

By the way, I could be wrong, but my gluten tolerance has gotten better while also treating with disulfiram, I wonder if one day I may be free to eat gluten without any reaction, not like I would want to considering the amount of glyphosate now embedded in the grain, but it would be nice to enjoy eating some organic pizza every now and then without being fatigued lol Once I put bartonella in remission, maybe, maybe not... However, the concern is that Bartonella has triggered Celiac for me just as reovirus has done for other Celiac patients.

Post Edited (Charlie55) : 3/17/2020 7:31:41 AM (GMT-6)

I have just read a blog about someone experiencing the same thing jb ! Holy moly this is such a tricky one , I am trying to educate myself as much as I can on mast cells but there is so much conflicting info right down to foods .. it really is what works for you ..

We went by symptoms. I had all the symptoms of high copper. Can't recall what they were exactly but seeing as copper made my histamine issues worse I believe my levels are high.

Tash, keep a food diary and see what is causing elevated histamines.

Charlie, that is great news. The literature isn't on our side of eating animal protein long term, I wish it was. Do whatever you have to do to get well but try to eat as much fiber as you can tolerate. Studies show that people who eat high fiber diets can eat animal protein without having the same adverse effects as people who just eat a lot of meat. I think 50 g a day of fiber is minimum for this so most don't get there. I've been looking into the debate of the ideas of Dr Gundry vs ideas of Dr Greger. I'll post on that sometime.

jb, if I had high copper, I'd be looking for blood borne infections or severe leaky gut which can be GI infections or food induced.

I supplemented copper once and it worked great for 3 days. After 3 days, it wreaked havoc on my system. I won't make that mistake again.

Post Edited (Georgia Hunter) : 3/18/2020 6:52:53 PM (GMT-6)