plaquenil damage

I have asked this ind of thing on here before but here i go again. I think 6-9 months of plaquenil and rifampin ( ESPECIALLY the plaquenil) I took 6 years ago ruined my health permanently and caused this chronic suffocation feeling I have had for years. I am wondering if anyone else took long term plaquenil and if so do you have any similar or other problems that resulted from it? https://www.facebook.com/notes/andy-cutler-chelation-safe-mercury-and-heavy-metal-detox/fluoroquinolone-side-effects/2098087433622984/ I am pretty sure plaquenil is a Fluoroquinolone ?

If this is the cause of my suffering body I am doomed cause if it is something to kill off ( an dinfection) or clear out ( a toxin) there is hope. But if it is permanent damage form plaquenil and rifampin there is no hope. just this forever looking for others who have done long term plaquenil and their experiences

I commented in other recent postings on using Plaq long term in a Lyme treatment combo therapy. It's best to have your eye doctor get a retinal baseline and have it checked annually is my best advise, Otherwise I found taking plaq long term was pretty benign compared to other higher risk Rx items.

ok so still learning here--- so plaquenil is a quinoline not a flouroquinoline?
so it doesnt cause the same damage as the floxing?
but I thin it can still cause damage, right?
that combined with rifampin malarone ( I think) and minocycline- I am having progressively worse tight squeezing ( nerves) and suffocating, heart issues.
I thought plaquenil was a very closely related to the flouroquinolines?

flowergarden said...
ok so still learning here--- so plaquenil is a quinoline not a flouroquinoline?
so it doesnt cause the same damage as the floxing?
but I thin it can still cause damage, right?
that combined with rifampin malarone ( I think) and minocycline- I am having progressively worse tight squeezing ( nerves) and suffocating, heart issues.
I thought plaquenil was a very closely related to the flouroquinolines?

Plaquenil is a hydroxychloroquine.
it is NOT a fluoroquinolone.
It is the fluoroquinolones (Levaquin, ciprofloxin) that have the risk of “floxing”

It can damage the retina - so it’s advised you see an Opthamologist to check for that.
It can also cause long qt syndrome that affects the heart.

Plaquenil can treat Babesia - Im wondering if it’s a dieoff of Babesia you’re experiencing...

Took Plaquenil (to inhibit progression of Lupus) for over 10 years without any issues. Did the annual eye exams as a preventative, but never had any eye issues.

Here's my history taking Plaq long term and in combo with other popular Lyme abx. I repeat...Plaq was always the least benign Rx I have taken in the past ten years. I do not list my many OTC Buhner and other supplements I've taken in parallel, as well as trial periods of Salt/C and even MMS I have tried in desperate times. I'm at a point where if someone told me to try drinking 2 quarts of Quaker State 10w40 a week like I used to feed by 67 GTO when in high school, I'ld give it a try... what's to loose at this point.

Past ABX protoclols:

1/26/20 to Present: Disulfiram (started 62.5mg, up to 500mg on 3/6), Baby Aspirin, Heart and Stint Meds
1/21/20 to 1/25/20: Bactrim DS, Biaxin, Baby Aspirin, Heart and Stint Meds.
10/20/19 to 1/20/20: Malarone, Bactrim DS, Biaxin, Nystatin. Baby Aspirin, Heart and Stint Meds.
9/26/19 to 10/20/19: Alinia (x2) Bactrim DS, Biaxin, Nystatin. Baby Aspirin, Heart and Stint Meds change.
8/13/19 to 9/25/19:Alinia (x2) Bactrim DS, Nystatin. Baby Aspirin, Heart and Stint Meds started.
4/20/19 to 8/12/19:Alinia (x2), Bactrim DS, Biaxin, Nystatin, Lipo OoO (ran out 5/2019), LDN (ran out 7/2019)
4/9/19 to 4/19/19: Alinia (x2), Rifampin, Biaxin, Nystatin, Liposomal Oil of Oregano, LDN full time
10/18/18 to 4/8/19: Alinia, Rifampin, Biaxin, Nystatin, Liposomal Oil of Oregano, LDN full time
7/9/18 to 10/17/18: Alinia, Rifampin, Biaxin, Nystatin, Liposomal Oil of Oregano full time
3/12/18 to 7/8/18t: Tetra, Diflucan, Alinia, Oregano 2 week on/3 week off pulse.
11/18/17 to 3/11/18: Tetra, Diflucan, Alinia 2 week on/3 week off pulse, added Liposomal Oil of Oregano
7/24/17 to 11/17/17: Tetra, Diflucan, Alinia 2 week on/3 week off pulse
7/1/17 to 7/9/17: Tetra 2 week pulse, ran out 7/9/17
6/14/17 to 6/30/17: Tetra, Alinia (ran-out) 2 week on/off pulse
5/27/17 to 6/13/17: Tetra, Diflucan, Alinia 2 week on/off pulse
5/1/17 to 5/26/17: Tetra, Diflucan, Alinia 2 week on/off pulse, continue Famvir full time
4/17/17 to 4/30/17: Ceftin and Bactrim full time after bite, added Tetracyline, continued Famvir
11/24/16 to 4/16/17: Pulse Ceftin and Bactrim 2 weeks on/off. Added Famvir fulltime.
9/24/16 to 11/23/16: Pulse Ceftin and Bactrim 2 weeks on/off.
7/28/16 to 9/23/16: Pulse Ceftin, Bactrim, Diflucan 2 weeks on/off.
7/7/16 to 7/27/16: Pulse Ceftin and Bactrim 2 weeks on/off. No refills left for Alinia
5/9/16 to 7/6/16: Pulse Ceftin and Bactrim 2 weeks on/off, Alinia full time
2/29/16 to 5/7/16: Nystatin, Cipro, and Plaquenil full time; pulse Ceftin 2 weeks on/off
2/15/16 to 2/28/16: Crypto, Nystatin, Cipro, Tetracycline, Plaquenil full time, no pulse.
12/7/15 to 2/14/16: Crypto, Nystatin, Cipro, Tetracycline, Plaquenil. ABX pulsed 2 weeks on/off
11/26/15 to 12/6/15:Rx Cryptolepis, Nystatin
9/23/15 to 11/25/15:Rx Cryptolepis, Cipro, Tetracycline, Plaquenil, Nystatin (liquid)
7/31/15 to 9/17/15: Rx Cryptolepis, Cipro, Minocycline
7/18/15 to 7/30/15: Rx Cryptolepis, Cipro
5/21/15 to 7/17/15: Rx Cryptolepis
4/16/15 to 5/15/15: Diflucan
3/19/15 to 4/15/15: Nystatin
2/1/15 to 3/18/15: Minocycline, Nystatin
12/17/14 to 2/1/15: Minocycline, Plaquenil, Nystatin
12/09/14 to 12/16/14: Plaquenil, Nystatin,
11/19/14 to 12/8/14: Plaquenil, Nystatin, Levaquin
11/12/14 to 11/18/14: Plaquenil, Nystatin, Minocycline
10/10/14 to 11/11/14: Plaquenil, Nystatin, Diflucan
9/8/14 to 10/9/14: Minocycline, Plaquenil, Nystatin
8/4/14 to 9/7/14: Minocycline, Plaquenil, Nystatin, Valtrex
7/8/14 to 8/3/14: Plaquenil, Nystatin, Valtrex
6/8/14 to 7/7/14: Minocycline, Plaquenil, Nystatin, Valtrex
4/19/14 to 6/7/14: Minocycline, Plaquenil, Nystatin
4/2/14 to 4/18/14: Doxycycline, Plaquenil, Nystatin
3/10/15 to 4/1/14: Coartem (last dose taken 3/26/14 am), Nystatin
2/6/14 to 3/6/14: Doxycycline, Plaquenil, Rifampin, Nystatin
11/23/13 to 2/5/14: Minocycline, Plaquenil, Rifampin, Nystatin
11/9/13 to 11/22/13: Minocycline, Plaquenil, Rifampin
10/30/13 to 11/4/13: Minocycline, Plaquenil, Parastroy,
10/20/13 to 10/29/13:Minocycline, Parastroy
10/11/13 to10/19/13: Diflucan, Parastroy
9/21/13 to 10/6/13: Coartem
8/16/13 to 9/20/13: Oral Minocycline, Bactrim DS, Alinia, Diflucan
5/23/13 to 8/15/13: Oral Minocycline, Bactrim DS, Tindamax, Alinia
4/1/13 to 5/22/13: Oral Minocycline, Bactrim DS, Tindamax
3/8/13 to 3/30/13: IV Doxycycline, Bactrim DS, Tindamax
2/5/13 to 3/7/13: Zithromax, IV Doxycycline, Mepron x2, Bactrim DS, Tindamax
1/21/13 to 2/5/13: Zithromax, IV Doxycycline, Actigall, Mepron x2, Bactrim DS, Tindamax
10/29/12 to 1/20/13: Zithromax, IV Rocephin (2x/4 days/wk), Actigall, Mepron x2, Bactrim DS, Tindamax
9/12/12 to 10/29/12: Zithromax, IV Rocephin (2x/4 days/wk), Actigall, Mepron x2, Bactrim DS
8/25/12 to 9/11/12: Zithromax, IV Rocephin (2x/4 days/wk), Actigall, Mepron x2
6/30/12 to 8/24/12: Zithromax, IV Rocephin (2x/4 days/wk), Actigall, Mepron x2, Diflucan
6/22/12 to 6/29/12: Zithromax, IV Rocephin (2x/4 days/wk), Actigall, Mepron x2
4/19/12 to 6/21/12: Zithromax, IV Rocephin (2x/4 days/wk), Actigall, Mepron, Bactrim DS
2/27/12 to 4/19/12: Zithromax, IV Rocephin (2x/4 days/wk), Actigall, Mepron
2/21/12 to 2/26/12: Zithromax, IV Rocephin (2x/4 days/wk, 3 days off pulse), Actigall, Rifampin
1/17/12 to 2/20/12: Zithromax, IV Rocephin (1x/day), Actigall, Rifampin
12/19/11 to 1/16/12: Zithromax, IV Rocephin (1x/day), Actigall
10/11/11 to 12/9/11: Zithromax, Doxycycline, Rifampin (STOPPED all due to elevated ALT/AST)
9/18/11 to 10/11/11: Zithromax, Augmentin, Rifampin
8/24/11 to 9/17/11: Zithromax, Augmentin, Mepron
6/29/11 to 8/23/11: Zithromax, Suprax, Mepron
5/10/11 to 6/28/11: Zithromax, Omnicef, Mepron
3/31/11 to 5/9/11: Zithromax, Omnicef
3/25/11 to 3/30/11: Biaxin, Plaquenil
3/18/11 to 3/24/11: Biaxin, Plaquenil, Diflucan
3/8/11 to 3/17/11: Biaxin, Plaquenil
11/4/10 to 3/7/11: Tetracycline
3/11/10 to 11/3/10: Biaxin, Plaquenil

Hey Girlie,

I have not yet tried Rifabutin, but it is very high on my list to try once I get a little further along in my current DSF and SFM paths. Without hi-jacking this thread too much, I'm only a month into a full 375 mg dose/day of DSF and feel like crap with increased insomnia and return of many familiar herx/replapse sx. Jury still out and see my LLMD on 3/4. Most likely will stay with DSF at current (or increased dose) for another 3 or 4 months or until I see some return to 90% or better levels.

Then I see Dr Novak on 3/9 for his SFN treatment recommendations and see if IVIG $$$ is my future.
I also filed for unemployment yesterday and am looking at what part time hours I may get as we start to come out this pandemic nightmare.

Other than that, social distancing is pretty boring.

later

Post Edited (tickbite666) : 3/26/2020 11:21:30 AM (GMT-6)

I beg to differ. I did cipro, and the first day, after 2 days on it, i had a severe tendon tweak in my elbow while bench pressing, and i am a big strong man. I had no idea i could not lift heavy while on this.

Later I had a 30 day course with the same, and that was the most horrible time ever. I cannot describe how bad it was, I lostt a year to this, and nearly offed myself. I came here, because I saw one dude in this thread nailing himself with abx.

I read ozone teraphy can help lymes disease. so wanted to give my two cents on that.

Rifampin stimulates the liver to produce CYP3A4 and some other cytochrome P450 enzymes. These enzymes can metabolize other drugs and also break down cortisol, stressing your adrenals. Also the color of rifampin stained my teeth a bit. The biggest problem with using rifampin long term is that bacteria tend to become resistant to it.