DoxyCicline plus Vitamin C/Ester C

Is this a protocol? Mino or doxy with vitamin c?

I have been on mino since Feb18 plus several months prior with my previous LLND.
I take vitamin C in the winter months

Hmmm I might try it.

How much C and how/when do you take it?

One more thing, one of the reasons of the good vit c effect, its because it also raises the blood levels of any tetracyclines on the blood and could decrease the vit c level at the same time, but that is a claim i found here, could not find more sources:

https://www.stlukes-stl.com/health-content/medicine/33/000994.htm

Did you took vitamin C it in the past with MINO on winter? If so, you have already done it without problems? If not, better to be safe and avoid.

I am taking 400mg doxy on the on days and didnt notice any problem. But mino could be a problem because of intacranial pressure side effect? Dont know, in these cases doxy is more safe than mino, atlought mino has a better penetration in the brain, they say.. but the difference on that is minor and not justifiable to take mino, but thats me..

250mg is a safer max dose of vit C. Too much and it will start suppressing immune system pretty badly.

improved chemotaxis does not mean a whole lot by itself

https://www.researchgate.net/publication/259203252_Antioxidant_Supplementation_Enhances_Bacterial_Peritonitis_in_Mice_by_Inhibiting_Phagocytosis

generally all antioxidants should be avoided with the exception to very little doses of vit C for its anti bacterial properties

Effect of mega doses of vitamin C on bactericidal ativity of leukocytes
https://pubmed.ncbi.nlm.nih.gov/327791/
Effect of ingesting mega doses of ascorbic acid was studied on the leukocyte function in five normal human subjects. During the first 15 days the subjects received daily supplements of 200 mg of ascorbic acid, and during the next 2 weeks they were given 2 g of vitamin C per day. Supplementation of 200 mg as well as 2 g of ascorbic acid stimulated hexose monophosphate shunt activity of resting leukocytes indicating an increase in resting metabolism. Intakes of 200 mg of ascorbic acid per day did not affect bacterial killing by leukocytes. On the other hand, daily intakes of 2 g of ascorbic acid for 2 weeks significantly impaired bactericidal activity. Four weeks after withdrawal of the vitamin supplementation, bactericidal activity returned to normal.
...
The mean ascorbic acid concentration in leukocytes at the beginning of the study was 9.3 ± 0.61 g/108 cells. At the end of 15 days supplementation with 200 mg of the vitamin per day and 2 g of ascorbic acid per day the levels increased significantly (P < 0.005) to 14.1 ± 0.39 g/10 cells and 16.1 ± 1 .02 g/10 cells, respectively.
...
Daily intakes of 2 g of ascorbic acid have been found to result in increased concentrations of cyclic adenosine monophosphate in blood (18). Boume et al. (19) have shown that cyclic adenosine monophosphate inhibits the killing of ingested bacteria . Circulating levels of cyclic nucleotides were not measured in the subjects investigated here and it is not possible to comment on this possibility.

The study you referred is from 1977, more then 40 years ago. Perhaps at that time researchers didnt had the tools they have now to see the real scenario.


There are studies like wish show it differently. This doesnt mean vitamin C in higher doses is for everyone and it can do harm in some people. Like everything it must be discussed with the doctor. My LLMD recommended 1000mg 3 /times a day and i dont take that because i think its too much. So its for one to decide with his doctor whats best


For example, this also a old one from 1989:

The effect of large doses of vitamin C on leukocyte function and some laboratory parameters

https://pubmed.ncbi.nlm.nih.gov/381229/


More importantly a more recent one from Sep 2019 wish helps us understand that our immune system is not only constituted by Leukocytes, you cant ignore NK cells, lymphocytes , neutrohils.

https://akjournals.com/view/journals/1886/9/3/article-p73.xml

Immunomodulatory Properties of Vitamin C
Furthermore, HIGH doses of vitamin C not only stimulated murine immune cells, primarily dendritic cells, to more distinct interleukin (IL)-12 secretion [40], but also activated T and B cell functions [34, 41].

Neutrophils
In support, oral administration of vitamin C has been shown to enhance neutrophilic functions and to result in increased serum immunoglobulin levels in aging patients [67]

T Lymphocytes
T cells are enhanced in the presence of vitamin C in physiological concentrations, whereas proliferation and viability of T lymphocytes are also affected [37]. In a clinical study with elderly patients who received vitamin C (500 mg/day) versus placebo for one month, an increased T cell proliferation could be assessed in the serum as compared to the placebo group [73].

Natural Killer Cells
Proliferation of human NK cells derived from peripheral blood mononuclear cells could be accelerated by co-incubation with vitamin C resulting in higher cell numbers with accurate functional capacity [84].

Summary and Conclusions
Leukocytes including lymphocytes can actively accumulate vitamin C against a concentration gradient, which underlines not only vitamin C dependent functional but also developmental immune cell features. In fact, vitamin C has a pivotal impact on both innate and adaptive immune responses. Vitamin C is also involved in bacterial metabolism. It is known that several bacteria can ferment vitamin C, whereas the presence of this vitamin exposes others to oxidative stress, which may result in bacterial growth inhibition.

Post Edited (isitlyme) : 11/7/2020 4:26:17 PM (GMT-7)

> The study you referred is from 1977, more then 40 years ago.
> Perhaps at that time researchers didnt had the tools they have now to see the real scenario.

https://www.researchgate.net/publication/259203252_Antioxidant_Supplementation_Enhances_Bacterial_Peritonitis_in_Mice_by_Inhibiting_Phagocytosis

^ Well this study is from December 2013...

> The effect of large doses of vitamin C on leukocyte function and some laboratory parameters

only the net effect is important, not individual immune system markers...

> I thought you could take a lot of vit c without negative consequences ??

yes, all so called "anti oxidants" are bad news for immune system in excess - recall Mikhaila Peterson - she recovered from her chronic lyme strictly on the "anti oxidants" free diet

https://mikhailapeterson.com/my-battle-with-lyme-disease/
https://mikhailapeterson.com/lyme-disease-are-you-kidding-me/
https://www.reddit.com/r/zerocarb/comments/ayd6a3/mikhaila_peterson_diagnosis_lyme_disease/

.. i'd personally pulse Vit C no more than 250mg per 3..4 days

Post Edited (Dmitry) : 11/8/2020 8:35:38 AM (GMT-7)

By the way, if we want to find examples about effectiveness of vitamin C on Chronic Lyme we will find it.

In Orthomolecular Medicine News Service Thomas E. Levy, MD, JD reveals the impact of Vit C and he gives several reports on diseases and partriculary Lyme. Although personally i would never take this Giga dose of this womans report, but it was termporarly administred not everyday.

https://riordanclinic.org/2014/09/the-clinical-impact-of-vitamin-c-my-personal-experiences-as-a-physician-2/

Chronic Lyme Disease

A woman with a 12-year history of chronic Lyme disease, documented by blood testing, desired having regular and prolonged high-dose intravenous vitamin C therapy for her condition. Under the aegis of a prescribing physician who had attended one of my presentations of vitamin C, a nurse practitioner was able to give the patient what she wished.

This individual had already been taking liposome-encapsulated vitamin C and glutathione orally without a significant improvement in her condition. On four consecutive days, she received infusions of 25, 50, 75, and then 100 grams of vitamin C. Then, for 19 more days, she received 5 or 6 infusions weekly of 100 grams of vitamin C in each infusion. Until day 23, she felt noimprovement. However, she was determined to continue in spite of the lack of improvement and the increasing expense of the whole process. On day 23, the nurse practitioner reported that she looked like a new person, and that it was like a “switch was flipped” and she was well. At her request, the patient received another week of 100 gram daily infusions to be sure her condition was truly resolved, a very good idea on her part. about a month later, her Lyme blood testing was completely negative.

A physician reported to me similar experiences with a series of Lyme patients, who showed no positive clinical response after an extended number of vitamin C infusions, then had a dramatic, abrupt clinical resolution of their condition, very much as described above.

Post Edited (isitlyme) : 11/9/2020 6:41:09 AM (GMT-7)