Patients can respond very differently to disulfiram. Be cautious.

interesting
after watching all of the available videos's from Bioneomed featuring Dr Rajadas on Disulfiram it was clear the formulation is critical to both maximize the antimicrobial effects of disulfiram and also to reduce the unwanted toxic effects mainly caused by its metabolites.

he states its necessary to encapsulate the drug so it is not absorbed until the colon - thereby bypassing the first-pass metabolism in the liver

since the two LLMDs patient populations seem to experience different antimicrobial activity and differing levels of side effects/tolerance i wondered if they might have been using different formulations?

Thank you for posting. I found this informative.

Does anyone here see Dr. DK?

it seems to work well for those with Lyme and Babesia in particular - less is known about its effectiveness for other co-infections -
but the mechanism of action against Borrelia has yet to be pinpointed - or even whether it is the parent drug that is most active - or one of the many metabolites it breaks down into in the body that is the most anti-spirochetal component.

although there are some LLMD's who feel it generally leaves the patient with better immune function than before disulfiram treatment ( mainly by its anti-inflammatory and anti-hypo-perfusion effects i believe). so there is some speculation that this in itself may help them clear some co-infections.

clinically - LLMD's are reporting somewhat less positive outcomes in patients that they diagnose or suspect Bartonella infection in.

then in the entirely unknown category are
anaplasma
Ehrlichia
mycoplasma
rickettsia
etc

at least this is the information i have picked up from my reading/research

This statement in the article was a shocking and sobering revelation:

“It is now clear that alcoholics tolerate disulfiram much better than those of us with chronic Lyme. It seems that alcoholics’ detoxification capacities are in better shape than patients with chronic tick-borne infections, at least until alcoholics develop cirrhosis.”

WalkingbyFaith said...
This statement in the article was a shocking and sobering revelation:

“It is now clear that alcoholics tolerate disulfiram much better than those of us with chronic Lyme. It seems that alcoholics’ detoxification capacities are in better shape than patients with chronic tick-borne infections, at least until alcoholics develop cirrhosis.”

yeah, i caught that too.

i think it's referring to the fact that alcoholics' bodies actually adapt to deal with the toxins so they are able to drink way more alcohol than the rest of us. ( before he became sober - my father used to drink 10-15 pints of beer, a bottle of sherry, and then start on the hard stuff!
then do the same the next day....) so their livers have adapted to detoxify better (for a time at least)

did you see in the history of disulfiram that at one point in the not too distant past the average life expectancy for a male in Russia was something like 50 years!!! due to alcohol consumption.

on the other hand, most with Lyme and co-infections will have impaired liver function. so one is a kind of super detoxifier and the other a poor detoxifier - I think that's the reason for a wide gap.