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Can you take milk thistle while you're on fluconazole?

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Posted 4/29/2017 10:13 AM (GMT 0)
Any idea if it is safe to mix milk thistle and fluconazole or not? Wouldn't milk thistle interact with how your body is processing the drug? Any ideas?

Thanks
Posted 4/29/2017 11:14 AM (GMT 0)
I took fluconazole on the weekends and 1 capsule a day of milk thistle for about 10 months. I do not know if it was safe or not. I was not told by my doctor not to take it. Hopefully, someone will have more information.
Posted 4/29/2017 12:30 PM (GMT 0)
Yes, you are correct - Some medications are changed and broken down by the liver. Milk thistle might decrease how quickly the liver breaks down some medications - and diflucan is one of them. However, Diflucan can be toxic to the liver when taking high doses (I don't know what dose you are on), so I would definitely be careful. Is there something you can substitute milk thistle with? What are you taking it for?
Posted 4/29/2017 4:05 PM (GMT 0)
I'm taking it for candida to prepare for antibiotics. I'm on my first dose which is 100mg. I haven't had any die off effect 24 hours into it which is making me think candida may not be a big issue for me.

Also I read fluconazoles half life is quite long so for that reason I don't think I'd use it more than once a week.
Posted 4/29/2017 5:30 PM (GMT 0)
My LLND said it was fine to take Milk thistle with the Flucanazole.

I hadn't read there was an issue.

I'm wondering if it's to do with the Cytochrome P450 ?
Posted 4/29/2017 8:58 PM (GMT 0)
There is, Girlie, forgot which enzyme....

Xelae - I was on diflucan daily for 2 weeks at a clip when I was aggressively treating Candida. yes, it has a long half life, but my dr had tremendous success giving it to patients in that way. Many people though, take it either every 3 days, or pulse it on weekends when they are treating candida, and take it either weekly or once a month for maintenance

I wouldn't expect die off right away, and some people don't really experience much die off with diflucan. I didn't have any die off, I just got better when I took it.
Posted 4/30/2017 2:13 AM (GMT 0)
I take 200 mg of diflucan daily for candida, and my Dr said taking milk thistle is a must! She it won't interfere with the med, it will help protect your liver and keep your detox pathways clearer. Diflucan is hard on the liver, so it's important to support it with things like milk thistle and dandelion root tea. I'll be on nystatin and diflucan daily for a total of 3 months to kill candida. Definitely try milk thistle to support your liver. God Bless.
Posted 4/30/2017 2:41 AM (GMT 0)
Here is a list of stuff milk thistle interferes with according to my LLMD:

MILK THISTLE DRUG INTERACTIONS:

Milk thistle can increase levels of the following drugs:
Methadone
Medications for AIDS
Heart meds: tambocor (flecainide), Rythmol (propafenone)
Erythromycin, rifampin
Anti-seizure drugs carbamazepine (Tegretol)
Antidepressants: St. John’s Wort, Zyban/Wellbutrin (bupropion), Paxil (paroxetine), Prozac (fluoxetine), Luvox (fluvoxetine), Serzone (nefazodone), Effexor (venlafaxine)
Antihistamines: Hismanol (astemizole), Seldane (terfenadine)
Anti-fungals: itraconazole (sporanox), Ketoconazole (nizoral),
Gastrointestinal motility agents: Prepulsid (cisapride)
Ergot drugs: ergonovine, ergomar (ergotamine)
Anti-psychotics: Clozaril (clozapine), Orap (pimozide)
Sedatives/sleeping pills: Ambien (zolpidem), Halcion (triazolam), Versed (midazolam)
Lipid lowering drugs (statins): Lescol (fluvastatin), Mevacor (lovastatin), Pravachol (pravastatin), Zocor (simvastatin), Baycol (cerivastatin).
Transplant drugs: cyclosporine (neural, sandimmune), prograf (tacrolimus)

Milk thistle has the potential to lower levels of the following drugs:
Antiparasite drugs Mepron (atovaquone)
Sedatives/sleeping pills: Ativan (lorazepam)
Hormones: Estrogen
Posted 4/30/2017 1:20 PM (GMT 0)
healingdaily - Hi! I am curious, how long are you taking the diflucan 200mg? I am going to do another 10 days of it in the next week or so, and the last time I did that it was in December. Still battling Candida.
I appreciate your advice on the milk thistle, I know diflucan is hard on the liver, but I do worry about it not working as well if taken with the milk thistle - since you have been doing this, has the diflucan been doing it's job?? I never took anything with diflucan, and my liver was ok, but I do think this is great advice.
Posted 3/22/2021 8:49 PM (GMT 0)

Healingdaily17 said...
I take 200 mg of diflucan daily for candida, and my Dr said taking milk thistle is a must! She it won't interfere with the med, it will help protect your liver and keep your detox pathways clearer. Diflucan is hard on the liver, so it's important to support it with things like milk thistle and dandelion root tea. I'll be on nystatin and diflucan daily for a total of 3 months to kill candida. Definitely try milk thistle to support your liver. God Bless.



Can we take liver life with diflucan same time or before after taking it ?
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