lapis - think you are asking for something which does not exist in the way that you have phrased the question
to try to explain
to prove that definitively, someone would have to pay for a super expensive placebo controlled human trial with sufficient statistical power ( hundreds of human patients in each arm ) to draw robust conclusions
the cost for this would be several million dollars at minimum
however, the drug is when last i checked not FDA approved - so the above trials could not even be started
estimated for this FDA approval cost are in the range of 50million dollars
we are all desperate for a cure for this awful disease - so i sympathise with the wish to believe in a cure. but if we are really interested in the truth of a situation we have to go in looking at the whole picture - not only the parts we would like to be true.
if we are really interested in understanding the nature of something, we should not set the bar for what we will accept as true as being something which rationally we can see will be exceedingly unlikely to ever be done, or not possible to be done at this point in time - then say - that because it has not been done - this is evidence that the opposite is true.
that would be a clear distortion - and one which we would have been a willing participant.
in the absence of the kind of categoric proof which cannot yet exist - we have to look at the evidence we do have
that evidence is very clear that borrelia ( and in fact many bacterial organisms ) have persister cells in their populations at all times - especially those like borrelia that form biofilms
these persister cells have the genes that cause them to metabolise and exchange substances with their environment switched off - and the very mechanisms that antibiotics target - like protein synthesis or DNA synthesis - are not in use - and this is the reason that they are not killed by antibiotics - even at 1000x the concentrations achievable in human tissues and known to kill their non-persister siblings
then when the antibiotics are removed - these dormant cells can replicate again
Kim Lewis is very well aware of this - and talks about
it in his interviews
“Persister cells… go into dormancy… (and there is a) low probability random event we call molecular noise…cell where a gene – that gene was of – that cell goes into temporary dormancy – while it sent into dormancy antibiotics cannot kill it because antibiotics kill active cells – you get this small population of cells that survive the hit of antibiotics… you get a difficult to treat relapsing infection.”Dr. Kim Lewis
https://www.lookingatlyme.ca/2021/11/44-exploring-lyme-antibiotics-with-dr-kim-lewis/hygromycin A works by the same type of mechanism as most current antibiotics - by interfering with bacterial protein synthesis - this means that the above applies.
Global Lyme Alliance who are partnering with Flightpath and Kim Lewis to make this drug available is careful to promote this as a means of stopping people getting chronic Lyme - by treating it when its acute phase - rather than treating chronic Lyme
“Building upon this discovery, GLA is proud to partner with Dr. Lewis and Flightpath Biosciences,” says GLA Chief Scientific Officer Timothy Sellati, Ph.D. “The latter will usher hygromycin A along the commercialization path, through clinical trials and FDA approval, and ultimately into the hands of physicians struggling to prevent potentially tens of thousands of future Lyme patients
from developing PTLD or chronic Lyme disease”
https://www.globallymealliance.org/blog/hygromycin-a-whats-nextpeople with chronic Lyme will undoubtedly try hygromycin A - and it may prove to be more effective than say doxycycline - and could be useful in treating chronic lyme as part of a combination protocol - just as other antibiotics are used today.
my caution is, based on what is know about
the biology of borrelia and persister cells, along with the careful words of the researchers and lyme advocates actually involved - just to highlight that it is unlikely to be the kind of silver bullet to pin our hopes on.
again its not my job to convince you of something you do not want to believe - but you asked the question that i am trying to answer as helpfully as i know how.
Post Edited (Garzie) : 1/29/2023 3:28:37 PM (GMT-8)