Lipophilic natural antibiotics with small molecules capable of penetrating the blood brain barrier?

I have neurobartonellosis. Recently I tried garlic, like 5-6 cloves twice a day and I was greatly surprised. It has allicin, which is lipophilic and is a small molecule, capable of passing the blood brain barrier. I got a significant herx in my head from it.

Are there other natural compounds like allicin, capable of penetrating the bbb?

carvacrol and cinnamaldehyde

https://pubmed.ncbi.nlm.nih.gov/31801196/

Be a little cautious with this, because many compounds can cause stationary phase bartonella to return to active phase instead of dying.

Yeah, just because something is "natural" doesn't mean it has no side effects. I particularly found this with cryptolepis.

I killed bart with valproate and minocycline, which is lipophilic and crosses BBB, but doesn't meet your natural requirement. Also valproate (without mino) made bart flare majorly. I don't know if related chemicals like 2-methylbutyric acid or isobutyric acid would have the same effect, but you could try some herbals which contain those.

By bartonella flare, I mean the symptoms got worse and the bartonella didn't die. I got a lot more skin rash and bloody nose. The bartonella actually died from minocycline, which caused a herxheimer reaction (fever and a lot of detox).

https://www.ncbi.nlm.nih.gov/pmc/articles/pmc2697631/

So is valproate an antibiotic of some sort to which Bart can develop resistance? Because if it can, is rather prepare with more abx before starting using it.

monolaurin may work in the same way - has antimicrobial activity against both bacteria and enveloped viruses - through membrane disrupting effects it is thought.

Quin said...
Monolaurin is too easily metabolized in the human body. It seems unlikely that you could get enough to have much of an anti-bacterial effect.

and yet many people here seem to experience a very strong herx like reaction to it .....

Quin said...
I recall this thread

https://www.healingwell.com/community/default.aspx?f=30&m=4183840

The reviews were mixed, some reported herxing and others said it had no effect.

i don't doubt it - but then the same is true of many pharma antibiotics - so its hard to say.

i tend to think the fact that even some people have such strong herx like reactions to it demonstrates its doing some killing of microbes - at least in some people.

i know you do your own science based research Quin - but i wanted to mention also that there seems to be general conflation in the popular health world between Lauric Acid - a common fatty acid found in coconut oil - and monolaurin itself.
it seems to go along the lines of monolaurin is made from lauric acid - and therefore lauric acid will do the same thing in the body - and coconut oil is around 40% lauric acid - so you can get the same effect from coconut oil.
i believe its is thought the human body may be able to convert some lauric acid into monolaurin naturally - but to my knowledge the mechanism for that has never been bottomed out. so to what degree or in how many people is as yet undefined, it may be due to enzymes made by only certain gut bacteria for instance.

anyway - i wonder if this could be part of the reason for the mixed reputation of monolaurin