Psilocybin anyone .....? (long post warning)

long post warning - the below is copy and pasted from a post in the breaking down bartonella facebook group - i thought it was interesting so thought it worth posting here.

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I wanted to post in the chronic Lyme groups/morgellons and also the psychedelic therapy group regarding my recent 15g psilocybin trip. This is day 7 out from the trip. I took 15g over the course of 4 hours. I did this with the intent on getting some relief from chemical inflammatory response syndrome and 8 chronic stealth pathogens (6 borrelia species. Babesia microti, bartonella hesalae)
”chronic Lyme”
Here are my Lyme timeline statistics: Tick attached for several months in 2019 (don’t ask..it happened…got stuck). Tick fell off during a scabies treatment at the end of november 2019. December 5th 2019 acute Lyme flu. More like temporary late stage aids and every disease you can imagine happening all at once while youre blasted by radiation..I got a clinical diagnosis and extended “aggressive” antibiotic treatment of babesia, bartonella and borrelia on January 20th 2020. Life becomes that crapty panel of that awesome Heironymous bosch painting where everything is hell in every regard in that painting..the confusing ass herxes and symptoms only the sickest **** scientists could dream of… or just .. we all know how ****ing crap life can be during this painful recovery of killing off pathogens and dealing with mycotoxins etc..
During the spring ofl 2020 I did some research and found an article about a woman “overdosing” on LSD and it curing her pain pill addiction and her chronic lyme pain:
https://www.insider.com/woman-who-overdosed-on-lsd-said-it-cured-lyme-disease-2020-2
Then i found some existing research on the effects of psychedelics and saw that jon hopkins was set to do a study on psilocybin and chronic lyme:
https://www.sciencedirect.com/.../pii/S0165247820303977
https://hopkinspsychedelic.org/about
..(as an added synchronicity i just found the clinical trial info link for the jons hopkins university study on psilocybin and chronic lyme: https://www.clinicaltrials.gov/ct2/show/NCT05305105 looks like it starts at the end of this month. Maybe there’s still time to sign up for those interested. The description of the study copied from the webpage lists their protocol for the study:
This is an open-label proof-of-concept trial in which participants will complete an 8-week course of study treatment including two psilocybin sessions (15mg in week 4 and 15 or 25mg in week 6) with psychological support, and follow-up assessments 1, 3, and 6 months after the final psilocybin session.
With all of that in mind the following are what I think are to be informed opinions or inferences based on some of the studies and just the invaluable direct psychedelic experience itself and the possible mechanisms at play with chronic Lyme relief:
I've had a moderate amount of experiences with psychedelics beforehand so I knew them in a very different but just as special way...the research and the anectdotal stuff for Lyme remissions is another amazing testament to psychedelics.
The article where the woman foams at the mouth..I think that the foaming a the mouth is part of the body detoxing the toxins..hopefully germs?! I think there's some intense good stuff happening when a person takes a high dose to where physical purging is induced..
I snotted up a bunch during the trip the other day. I coughed up a bunch of stuff. I kept having to spit up crap..I think this is an actual physical detox effect that can be measured. I felt a lot better afterwards. I know Ayuhuasca is one that is known for these physical purges.I’ll bet ayahuasca would also yield the best results for chronic Lyme.
I don’t think these things really kill kill the germs but I do think that they repair damages to the innate immune system and allow for better and more streamlined detox.
I think that the time window of neuroplasticy while the psychedelic is active is important in this resetting of the innate immune system or any limbic system retraining. This could probably be bolstered by different techniques...things such as DNRS I think work in similar ways. Combining these would probably be amazing. I'm going to keep experimenting but not with 15g doses. Probably 2 or 3 into a weekly or biweekly routine. I want to keep my brain in a constant neuroplastic state to retrain it. Just the state alone may retrain it? That's what it seems like..
I think these psychedelics also calm the innate immune system so there are less cytokine storms. The benefits of recovery are numerous because the body cannot heal with a constant cytokine storm.
I also think this may have a postive effect on people with chemical inflammatory response syndrome and the bodies inability to detox biotoxins/mycotoxins. It feels like psychedelics balance all of this out and alows for more efficient detox...

interesting - thanks for chipping in Loski

my own experiences with psilocybin go back to my youth where a groups of my friends and i used them recreationally for a while - we all then sorted out lives out and went off got high power jobs!

there are some recent studies out of the UK where it is been used in kind of standard trip doses in a controlled setting with psychotherapy support - and is showing quite impressive effects for patients with treatment resistant depression who have failed the standard all the anti-depressant regimes.

they only give one of two doses and the studies show dramatic improvement still present weeks or months down the road

the most recent study show measurable changes in the "connectedness" of different brain regions in patients afterwards vs before via use of functional MRI - even weeks afterwards - which is pretty amazing

the clinical trial lead was interviewed on the BBC the other day and seems like a really good guy - he explained that what they believe is happening is that subjects with severe resistant depression have brains that are stuck in certain thinking patterns that are unable to rationalise or think their way out of - the psilocybin sessions effectively unblock those stuck thought processes allowing subjects brains to function better and find new ways of thinking that alleviates their depression.

he did warn that many patients experiences of the trip itself was "harrowing" - even though the end result was very beneficial - and of course strongly advised against self administration for people with mental health issues.

i can definitely see how that could be the case - especially if supported by a therapist that could help guide the person through the process.

micro dosing is interesting also - some people advocate this for similar benefits without the potentially disturbing nature of the trip

High QUIN (Quinolinic Acid) in brain is seen elevated in Neuroborreliosis patients as well as depression, generalised anxiety, nearly all neurodegenerative disorders, HIV/AIDS and suicide patients, MS, Lupus, among other diseases.

There is a direct correlation with elecated QUIN and neurological problems that are physical and not completely "in your head," as the deniers like to claim.

I do wonder if pscilocybin plays a role in supressing QUIN or if it works on the EAAT2 pump expression to pump out glutatmate from the NMDA synapses, thus ameliorating the endo, excito and neurotoxic effects of QUIN.

I know exactly what elevated QUIN feels like and there are tests to see levels but they're expensive. The overfiring of the NMDA receptors, interestingly, can result on the other end of the extremity, anti-nmda receptor encephalitis where your own immune system destroys the NMDA synapses which can cause psychosis like symtoms, akin to fully blocking NMDA receptors, which is oddly how Ketamine works.