Folate and B12 deficient on dapsone

After 3 months of dapsone I have folate and b12 deficiency.
I have been taking folate during the dapsone time, about 5 to 10 mcg minimum via one supplement. Other had Folic Acid 5mg.
It wasn't enough. Taking supplements pills doesn't seem to effectively maintain vitamin levels.


What is the best to best folate and b12 back?

Post Edited (newuser22) : 6/6/2022 12:45:39 AM (GMT-6)

LabRatDeluxe said...
Which type of folate do you take

Folic Acid 5mg

Girlie said...
When I was on Dapsone, I took Leucovorin.
It was a prescription.

10 mg a day

This folic acid turned out to be useless, it didn't prevent me from being deficient.
It takes 3 to 4 months to become deficient in folate, I took high dapsone for 3 months. and even after stopping dapsone the deficiency seems to get worse.

My doc didn't prescribe any folate or Leucovorin.

It says here https://tespovitamins.com/the-benefits-of-methylfolate/

Somebody said...
There’s nothing wrong with folate by itself. But, here’s the catch — folate is a B vitamin is water-soluble. Some people have a gene mutation affecting the MTHFR enzyme. For these people, their bodies are unable to convert folic acid to Methylfolate. Therefore, it’s critical that they not take folic acid. They should take Methylfolate instead, to bypass the need to convert the folate.

If you have the gene mutation, or a digestive condition, and you are taking folic acid, you could end up with unmetabolized folic acid and Methylfolate. They’d be competing for attention in your body, which has been linked to poor immune function, and a host of other health conditions.

LabRatDeluxe said...
It says here https://tespovitamins.com/the-benefits-of-methylfolate/

Somebody said...
There’s nothing wrong with folate by itself. But, here’s the catch — folate is a B vitamin is water-soluble. Some people have a gene mutation affecting the MTHFR enzyme. For these people, their bodies are unable to convert folic acid to Methylfolate. Therefore, it’s critical that they not take folic acid. They should take Methylfolate instead, to bypass the need to convert the folate.

If you have the gene mutation, or a digestive condition, and you are taking folic acid, you could end up with unmetabolized folic acid and Methylfolate. They’d be competing for attention in your body, which has been linked to poor immune function, and a host of other health conditions.

I did 23andme. I know I do not have MTHFR issue.
Puzzling part is this folate deficiency is very tricky, it is effecting major organs. it gets worse even after stopping dapsone when body's b9 stock pile is emptied. My pancreas got into trouble.