Peptides for Lyme Disease and co-infections

thanks for the updates and reasoning Rainy

it makes sense to me - not too extreme - and within the bounds of the available sources

its not something i have looked into in any depth so i am finding your experiences interesting

good to know there doesn't seem to be a high occurrence of adverse effects also

good luck and keep me posted

if i can help in any way - just reach out

dcd & Garzie check this out:

B7-33 Peptide:

B7-33 exibits potent anti-fibrotic effects. It is under active research and investigation as a means of reducing fibrosis in acute and chronic diseases like heart failure, lung inflammation, kidney and more.
In animal studies, B7-33 has reduced fibrosis by roughly 50%, leading to prolonged survival following injury and offering the first new means of treating heart failure in 20 years.
It has been shown to reduce excessive scar formation following cardiac injury. It has also shown promise in the treatment of certain vascular disorders as well as preeclampsia of pregnancy.

Very cool rainy. There are so many cool peptides out there popping up. I was always interested but a little dubious about how well they actually work in practice, until I felt the effects of ARA. Have a renewed interest now.

Just bought some TB Frag 1-4 to explore for my enthesitis. It's also been shown to benefit neuropathy in high doses

I would try B7-33 after I look into it, def seems up garzie's alley w/ the biofilms

KPV is another one that could potentially help my enthesitis

Post Edited (dcd2103) : 6/8/2022 5:46:22 AM (GMT-6)

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

https://pubmed.ncbi.nlm.nih.gov/18092346/

For those interested in KPV, Dr. MR sells it in his online store, no prescription required it seems. Very cool. It's an oral spray.

another interesting one Rainy

looks like they are starting to get deep into how these peptides may be exerting their effects

btw - dendritic cells are actually a form of immune cell - rather than a nerve cell - they process antigens and express them on their surface for other parts of the immune system to act on.

both neurons and dendritic cells have dendrites ( tree like structures on their surface ) which might lead to confusion between them.

the mention of IDO in the paper caught my attention
its a chemical or enzyme in the brain that i think gets upregulated in chronic brain inflammation ( eg lyme in particular ) an this upregulated IDO drives the tryptophan metabolism in the brain towards more quinolinic acid - which has excitotoxic and neurotoxic effects and is attributed many of the inflammatory changes in the brains of lyme patients
this is the short form from my memory of buhner's books where he writes about it at some length

i was interested in it as my OAT tests showed 10x higher than normal quinolinic acid levels

the paper is however rather dense and i haven't yet deciphered what if anything it is saying about Quinolinic acid and thymosin Alpha

I will be looking into peptides with my doctors. Thanks for the info

I had a really hard time finding the dosage for KPV injections.

Finally found this website that specifies the following dosing:

Please note that oral is in milligrams and injection is in micrograms!
It's easy to make a mistake like that.

From: https://jaycampbell.com/gut-health/kpv-the-anti-inflammatory-peptide/#ftoc-heading-11

Oral (via tablet)
Two 250 mg capsules taken with or without food, until your ailment is healed
Doses can be as high as 2000 mg per day depending on the condition being treated
Best used for treating Crohn’s disease, ulcerative colitis, and irritable bowel syndrome (i.e. gut problems)

Subcutaneous Injection
200-500 mcg injected once a day
Best used for treating overall systemic inflammation

Topical Cream
7.5 mg applied to the affected area twice a day
Best used for treating psoriasis and cystic acne

As far as safety goes, the patent has some dosing information, but it's a ridiculously high dosage. So keep in mind that it's just a patent, I'm not sure if it holds value clinically. However, it's nice to see even the very high doses didn't kill anyone...

Patent said...
For intravenous administration, for example, to a patient suffering from arthritis, or severe allergic reaction or various other diseases involving inflammatory processes, it will generally be desirable to administer about 0.2 to about 3.5 mg/kg/day of the agent by slow infusion over a period of time (up to several hours).

Where infusion is impractical, the agent is administered in the form of an intramuscular injection, preferably in combination with a lipophilic carrier and at somewhat higher doses.

For the treatment of mild to severe arthritic episodes, it is generally recommended that a (oral) parenteral dose of on the order of about 0.3 to 1.5 mg/kg/day, preferably about 0.5 to about 0.6 mg/kg/day.

However, for severe allergic reactions, higher doses on the order of about 2.5 to up to about 4 mg/kg/day may be indicated.

Patent can be found here: https://archive.org/download/kpv-patent/kpv_patent.pdf

Hey rainy,

I'm doing a little better. I got back on IVIG (from 8 wasted months on SCIG, it just doesnt work subcutaneously it seems). It has taken the horrible nerve pain that i've been experiencing for the past year (while off IVIG) down from a daily pain score of a 6-8 down to a 1-2. Dont want to jinx myself or declare victory, because I'm sure i'll have flares, but it's really just been such a game changer and I'm so glad to have some feeling back in my feet and that fully body burning under control. I was really beside myself past 6m or so, and this has given me back the ability to have some semblance of normality and actually wear shoes and do things

The only issue is that I'm still dealing w/ this arthritis. As I've mentioned its a form called enthesitis, which is just very bad news. It's the other half of the immune system, t-cells, so IVIG wont touch it. It goes away for a month or so at a time, until i accidentally eat or take something that triggers it, and then it goes uncontrollable for anywhere from 7-20 days. It looks like I will have to start some sort of DMARD to control it.

If i didn't have this damn issue I'd be happy as a pig in sh**. It seems like it was triggered by a bad reaction to cellcept in early 2020, went into remission as enthesitis often does, and was brought out of hibernation by the vaccine.

GHK-CU is awesome. It's in an anti-aging cream I bought directly from the owner of Limitless Life Nootropics, he hasnt even released it for mass distribution yet, but several members in the peptides group i'm in showed before and after pics, and it really is just a wrinkle-fighting machine! I'd recommend getting this cream if you are having issues w scars, DM francesco d'anconia on FB and ask him to buy some.

Issue is that almost every peptide triggers enthesitis for me. ARA-290, larazotide acetate, bpc, ghk-cu. Even collagen peptides supplement. It's like my body has decided that any amino acid chain shorter than a protein is no bueno.

Post Edited (dcd2103) : 9/19/2022 8:11:28 AM (GMT-7)

lol prob should resubmit they let everyone join.

They prescribed cellcept because its known to help neurological autoimmune. It causes a temporary joint pain in a small number of people. My body just did not like it at all, i got severe vertigo and nausea too, and i think the insult from whatever join pain it causes triggered my t-cells. Maybe this means that they were already primed, i dunno.

I no longer believe that lyme triggered this. I actually the more i think about it the more i realize the autoimmune started with a surgery. In 2012 I had a blood clot. They said that my clavicle pushed up against my 1st rib and pinned the vein. Thoracic outlet. In order to remedy this from ever happening again, they had to remove the rib. Brutal surgery that i had to stay overnight in the hospital for a week for. In order to remove the 1st rib they need to cut a nerve bundle that innervates the armpit and upper bicept area. I'm now permanently numb in that area on my right arm.

Well, i went into that surgery healthy. It wasnt until i was looking through old emails that i found a picture of my hand turning platinum white in the winter that I'd sent to my mom. Reynauds. It was taken a few weeks after that surgery and I was diagnosed with possible autoimmune reynauds not long after that.

I went into that surgery perfectly healthy, and a few weeks later I have my first neurological symptom. And they cut a huge nerve bundle (nerve matter spewing out into the extracellular matrix). My ANA was measured as positive when the migraines began 1y later. So I now think that's what likely first triggered the autoimmunity.

Def try it topically. The stuff i ordered from D'Anconia is like $60, has some other healing stuff in it that should help.

Great hearing from you too rainy, hope you are doing better as well!

Post Edited (dcd2103) : 9/19/2022 11:49:42 AM (GMT-7)

Garzie said...
good to hear you have made some progress and are getting at least some respite from the pain dcd

i heard something today that might be worth you looking into

apparently in the last year a so a company called pendulum in the US has developed the first Akkermansia muciniphila based therapeutic probiotic - its a big deal because until now these anaerobic organisms - and in fact 99.5% of the strains that live in the gut - have been off the table.

reading your post reminded me of it because its a beneficial bacteria that lives in and regulates the mucous layer in the intestines without which the gut is prone to inflammation and leaking molecules that should stay inside it into the body ( leading to many inappropriate immune reactions ) - and things in the body into the gut.

your extreme reactions to so many small molecules and peptides, and also the progress you made on keto and low fibre diets makes me think that the gut is leaky and that this might possibly hold some promise to help seal that up again at some at some future point for you.

just a thought in case its an avenue that might help

https://pendulumlife.com/products/pendulum-akkermansia

Interesting, thank you garzie. I will definitely look into this! I believe I have a leaky gut as well. So many layers to this onion.

dcd2103 said...
Hmm from my 2021 GI maps my akkermansia muciniphilia was flagged as high, about 15x upper end of normal, werid

interesting - will check mine - as i had a GI-Map done a couple of years ago

i remember the results i had from U-Biome ( the biggest Gut microbiome mapping firm out there at the time ) and GI-Map were totally diametrically opposed - to the point where there is no way they could both be right -
i mean totally opposite results - stuff that was measured as super high on one was super low or not present on the other
same for my ex-fiancé also - tested at the same time.

since U-Biome was shut down for dubious practices - i kind of concluded that they were more likely the unreliable one - but who knows ....

Garzie said...
OK - i checked my Ubiome and GI-Map results from 2018 - when i was 3.5yrs into the illness and in pretty bad shape

my GI map result did not include akkermansia, unfortunately - it may be something they added later - as interest in this genus has increased in recent years

Ubiome did detect it - at around 0.24x the normal levels - so low in my case - if you believe Ubiome results - but given that most of them were teh reverse of expected and the reverse of the GI-Map test - which i feel is a better company - perhaps it is high in my case too?

it could even be that when measured in the stool - conditions that cause break up of the mucin layer could carry both the mucous and the mucin eating bacteria out in the stool - and result in more akkermansia dna in the sample - but less in the gut - as its not really measuring where it really counts.

interesting stuff - but we only have a few of the pieces of the jigsaw it seems

onwards and upwards though!!

Yah it wasnt on my 2019 GI Maps, but was on my 2021. I do wonder how accurate any of these are, might just depend on what part of the stool its sampled from.

That being said i mentioned this to a friend w/ ankylosing spondylitis who is very into the microbiome stuff. He said that there's some literature that people w/ spondyloarthopathy, of which my Undifferentiated Spondyloarthopathy falls under the umbrella of, are shown to have either significantly elevated or depleted levels of Arkkemensia.

Seems like mine is quite elevated if the GI Maps is to be believed.