anyone else have a Genetic Vit B issue

FYI I have been on different multis (all high in VitB) throughout this year and before and just stopped as I think that may be contributing largely.

Not anymore hopefully but spent a lot of years in moldy situations. I agree the urination stuff does sound like mold. but there is certainly something to this vit b issue I beleive.

@Medicalnerd I agree and feel the same. My brain cannot get straight. These are the toughest symptoms for me to deal with. I dont feel better taking methyl B either. There is def something to this. There are to many of us with these symptoms and these genetic issues.

What to do?

in my view consumer genetic testing is largely a load of marketing BS that does a good job of building stories around products and getting people to buy the tests - but as anyone who has really dug down into the topic with any rigor will find - it quickly fails to live up to the hype - except of course via the power of suggestion and placebo effect.

at this point in time it falls dramatically short of delivering actionable outcomes to direct effective therapies -
the reasons for this are many:

-most biological functions in the body are driven by gene expression (which genes are switched on and by how much - ie epigenetics ) far more than they are by which genes or mutations are present in the genome - genetic testing DOES NOT measure epigenetics

- most biological functions are driven by the interaction of many, many genes - no a single gene - or even group of genes. We are no where near understanding the complex interplay between the multiple genes - the environment - and the epigenetic mechanisms that regulate them - the true complexity is enormous.

-even if you identify a gene mutation in what seems to be an important gene - current consumer genetic testing does not know if you have other genes active that entirely compensate, or even if your particular mutation is in fact better than the common wild type.

-many studies show that when when mutations are present and the efficacy of the mutated gene known - the influence of lifestyle and environmental factors far outweigh the say 30% reduction in activity of the protein produced by that particular mutated gene .

these are the uncomfortable facts

But people want a simple test that rewards them with a simple action - "oh, you have this gene mutation - take this pill" - and the testing and supplement industry is only to happy to oblige.

we humans like certainty - "its my genes that are causing this - look, its there, on the page in black and white "

we are also drawn to stories that support our often fatalistic view - or perhaps even excuse our lack of discipline in doing the hard work on the larger lifestyle factors that could make a difference - but take a whole lot more effort -eg diet, exercise, sleep, stress management. reducing screen time, drinking less etc

ie "there is no point in doing these things as my genes mean that there's nothing i can do about it"

the companies selling the tests and supplements know all of this and take full advantage of it -
my advice is - do not believe the marketing BS - these technologies are no where near ready for general consumer use - its currently like working out what the total 2000 piece jigsaw puzzle is with only 5% of the pieces.
-----------------

NB. that is not to say that people who are chronically ill cannot have issues with B-Vitamins (or any vitamins for that matter) these diseases are famous for making some people outrageously sensitive to certain foods, supplements, herbs and medications, even the capsule shell used for many supplements has dramatic effects on some sufferers.

its just not safe to assume these effects are due to an individuals SNIP's - when there are way more variables in the mix

note also - bartonella is also thought to synthesize vitamin B6 directly and may be responsible for high vitamin B6 levels - i think references for its ability to do that have been posted here before.

that's just my point though astro

what do you really "know" as a result of the test

and how much is just a product of what we think we know, or imagine is the case after reading the report and joining up dots, after the fact with a kind of retrospective logic that is highly prone to confirmation bias.

these are dots that could in fact have many other explanations - or perhaps are not dots at all - but noise that our brains pick out as a pattern due to the positive suggestion of the report.

i read comments like "i have this methylation gene - so this/or that is happening to me because of that" here an on other forums all the time - and felt i had to comment - because aftr digging into it in some bepth myself i genuinely feel these people are being mislead by an industry that is preying on their need for answers - and what i try to do here is help people make sense of what are extremely challenging complex chronic diseases, that these tests do little to help.



as per the case stated above - its not that there are a few pieces of the puzzle missing - but majority of the picture is clear ( as the test companies and supplement suppliers would have us believe )

but the reverse is the case - almost all of the puzzle is missing - so much so that what is there is of little practical use. so its a matter of degree - and in this case the degree is important

we can of course easily convince ourselves that its valuable information - and that it "explains" multiple things about our health situation - most of us are prone to do this if we have already justified the expenditure to ourselves - but this is into the realms of belief - rather than fact - its just masquerading as factual.

of the people here i think it fair to state i have one of the highest appetites for information, and tolerance for complexity, as i think my writings will indicate - and in my view SNIP testing is at best 80% random number generator and 20% actionable information - and even then the most educated of us will struggle to determine which bits fall into which category.

just trying to save people the cost, time and energy of finding that out for themselves or being misled into believing there is more to it than there is.

@Astro @Garzie Thanks for the replies. You both make very good points. I tend to be more of the mindset of Astroman. But thats not to say you arent right about alot of things Garzie. Great thoughts on both fronts!

All in all I just think there is certainly something to this Vit B deal. I will continue testing the waters and see. I am hoping to start with a functional dr soon and the labs should be interesting all the same.

Going back to what Astro said "Maybe its a gut issue???" .......Definitely I believe is the bigger issue for sure.

Cell absorption ...... What a B@#ch, am I right? (:

Good thoughts. I like the idea of a new functional dr to take a look every now and then. Good to have a few pairs of eyes working the case. I do hope it resolves on its own.

I am not loosing sleep over what I know about my VitB issues. Dam if was to loose anymore sleep over the thoughts of what I know now Id be in big trouble. The topic came up because I was actually for once noticing a difference in my body and head after taking high doses of VitB and was relating this to my genic disposition.

I feel theres something relating there, and it most likey is coming from gut disfunction. VitB absorbs very strangely in the gut. Or atleast I have read so.