Peptides Update

crazy glasses !

has anyone here tried BP-157 - and if so what can you report ?

Yup, good memory Rainy. I've seen 3 n=1 cases of people developing alopecia while on TA1. Given alopecia is a t-cell disease, and TA1 modulates t-cells, it makes me too scared to try it. That being said, I've heard of some people who have done well on it.

BPC is probably the most used peptide out there. Again, lots of people who report that it helped them in some way; either with digestive issues, or even more commonly with the healing of injuries when injected directly into a joint or tendon. But as Rainy mentioned, anhedonia also seems to get reported as being a potential side effect of this peptide, and when it happens it sounds like it takes a long time to go away.

The 3 peptides which I only seem to see positive things about are:

1.) ARA-290. I keep mentioning this, but if you have nerve inflammation it can be super benefiical. It's also shown to lower A1C and potentially even lower the ANA marker in lupus. As I noted, I've gotten many people on this, and only 25-50% of the people seem to benefit, others report no change. Dont know why this is.

2.) KPV. I've not tried this one, but seems to be an all around well-liked peptide, especially if you have joint type inflammation and supposedly can even help IBD.

3.) Larazotide acetate. Was being studied by 9meters biopharma for celiacs disease. It's a simple peptide shown to literally lower zonulin levels and therefore close the tight junctions. I even owned the stock at one point. Unfortunately their clinical trial did not meet the end point for celiacs. The thinking was that even though it supposedly worked to close the tight junctions, in practice it had little clinical effect in celiacs as even small pieces of gluten could trigger disease. At least I believe that was what came of it. I know they were talking about possibly doing another trial in a smaller cohort that might possibly benefit. Regardless, I know a lot of people with autoimmune seemed to claim benefit in digestive issues when trialing this peptide. Has to be used daily for benefit tho.

The co-op I'm in is looking to potentially sythesize this peptide as well:
https://nervgen.com/pipeline/

The world of peptides is an excicting space and has a lot to offer, but definitely do your research before. That includes both reading whatever published research is available, but also talking to people who have actually trialled these things. I mentioned 3 peptides that were on my radar and I seemed to see good things about, but there are a lot more I'm sure.

Hi Dunn!

Nice to meet you and welcome to HealingWell! Seems like we are on similar paths, my primary symptom is fatigue as well and also share the same interest in peptides. I also can’t begin to tell you how much caffeine I’ve used over the years just to stay afloat. So you're in good company haha.

In regards to BPC-157 it's a tricky one because, with the exception of 2 studies (which I’ll link below), nobody knows exactly what it's doing to people in those anecdotal reports. But from an observational standpoint it appears to make people immune to stimulants. Including coffee, amphetamines and possibly more.

This is what has been keeping me away from BPC-157 as I can’t afford to lose another “crutch” in this battle with fatigue.

So here is study 1: https://www.sciencedirect.com/science/article/abs/pii/s0006322397002771

This study administered bpc-157 with amphetamine (and haloperidol). You might be familiar with adderall which is a type of amphetamine. That’s why this is somewhat relevant because it’s very loosely similar to what other stimulants like caffeine do.

If you scroll down to the last page it will mention:

“Thus, taken together, these data suggest that this pentadecapeptide could have a modulatory effect on the dopamine system. In the condition of increased dopamine release and synthesis induced by amphetamine, it could both prevent and reverse the consequent disturbances (i.e., stereotypic behavior).“

A few notes:

- By pentadecapeptide they mean BPC-157 here.
- Dopamine is is a neurotransmitter that plays a role in pleasure, motivation, and learning. Note that it says motivation, I’ll touch on this later.
- “Disturbances” is an interesting word. Because those “disturbances” are actually what you want when you use a stimulant.
- Stereotypic behavior would be things like increase in motivation/focus.

So essentially what it’s saying is that it keeps the dopamine system in check, but again, when you drink coffee or take adderall, that’s not necessarily what you are looking for. In those cases, you want the dopamine to be increased and not kept in check when you take it.

Here’s another study on it, that you might find interesting:

https://pubmed.ncbi.nlm.nih.gov/11978191/

I’ll skip this one for now but let me know if you want to go over it as well.

In regards to the MOTS-c, there was someone on the forum that kept the benefits (increase in energy) after taking MOTS-c. So that’s the good news. The bad news is that it did not do that for me. However, the fatigue that it caused was also not permanent. 1 or 2 days max if I recall correctly. So basically I just went back to baseline.

I should say though, I did an experiment recently in which I took methyl-folate for 1 or 2 weeks and then took MOTS-c. This made a big difference and lined up with what someone on PhoenixRising (a different forum) had mentioned.

That time I did not crash at all! So I wanted to let you know that just in case you try it. There’s a gene (the MTHFR Gene) that makes people process folate different that might also play a role in how this peptide affects people.

Let me know if you have any more questions and welcome to HealingWell!

Bummer about BPC-157 side effects.

In my case, the positives would fit my needs to a key:

promote healthy intestinal function,
improve leaky gut,
modulate healthy Th1 and Th2 immune function,
aid in tissue repair of joints, tendons, ligaments, and nerves,

Bummer X 2 on the negatives.